Leukocyte Extracellular Vesicles Predict Progression of Systolic Dysfunction in Heart Failure with Mildly Reduced Ejection Fraction (LYCHEE) - A Prospective, Multicentre Cohort Study.

Autor: Gąsecka A; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.; Laboratory of Experimental Clinical Chemistry & Amsterdam Vesicle Center, Amsterdam UMC, Amsterdam, The Netherlands., Siniarski A; Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.; St. John Paul II Hospital in Krakow, Krakow, Poland., Duchnowski P; Ambulatory Care Unit, Cardinal Wyszynski National Institute of Cardiology, Warsaw, Poland., Stępień K; Department of Coronary Artery Disease and Heart Failure, Institute of Cardiology, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland.; St. John Paul II Hospital in Krakow, Krakow, Poland.; Department of Thromboembolic Disorders, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland., Błażejowska E; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland.; Laboratory of Experimental Clinical Chemistry & Amsterdam Vesicle Center, Amsterdam UMC, Amsterdam, The Netherlands., Gajewska M; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland. gmgajewska@gmail.com., Karaban K; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Porębska K; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Reda A; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Rogula S; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Rolek B; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Słupik D; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Gozdowska R; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Kleibert M; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Zajkowska D; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Grąt M; Department of General, Gastroenterological and Oncological Surgery, Medical Universityof Warsaw, Warsaw, Poland., Grabowski M; 1St Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1a, 02-097, Warsaw, Poland., Filipiak KJ; Department of Hypertensiology, Angiology and Internal Medicine, Poznan University of Medical Sciences, Poznan, Poland.; Department of Clinical Sciences, Maria Sklodowska-Curie Medical Academy, Warsaw, Poland., van der Pol E; Laboratory of Experimental Clinical Chemistry & Amsterdam Vesicle Center, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Biomedical Engineering and Physics, Amsterdam UMC, Amsterdam, The Netherlands., Nieuwland R; Laboratory of Experimental Clinical Chemistry & Amsterdam Vesicle Center, Amsterdam UMC, Amsterdam, The Netherlands.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2024 Sep 24. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1007/s12265-024-10561-3
Abstrakt: Risk stratification in heart failure with mildly-reduced ejection fraction (HFmrEF) remains challenging. We evaluated the predictive value of advanced glycation end products (AGEs) and plasma concentrations of extracellular vesicles (EVs) for the systolic and diastolic dysfunction progression in HFmrEF patients. Skin AGE accumulation was measured using AGE Reader. Plasma EV concentrations were measured using flow cytometry. Among 74 patients enrolled, 13 (18%) had systolic dysfunction progression and 5 (7%) had diastolic dysfunction progression during 6.5 months follow-up. Leukocyte EVs concentrations were higher in patients with systolic dysfunction progression (p = 0.002) and predicted the progression with 75.0% sensitivity and 58.3% specificity, independent of other clinical variables (OR 4.72, 95% CI 0.99-22.31). Skin AGE levels and concentrations of other EV subtypes were not associated with systolic or diastolic dysfunction progression. Increased leukocyte EVs concentrations are associated with 4.7-fold higher odds of systolic dysfunction progression in HFmrEF patients.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: