Essential Oils of The Leaves of Syzygium hemilamprum (F. Muell.) Craven & Biffin.: Chemical Analysis, Antimicrobial, Mosquito Larvicidal, ADMET, and Molecular Docking Studies.

Autor: Viet Pham T; Hue University, University of Education, 34 Le Loi, 530000, Hue, VIET NAM., Luyen ND; Vietnam Academy of Science and Technology, Institute of Natural Products Chemistry, 18 Hoang Quoc Viet, Cau Giay, Caugiay, VIET NAM., Quan PM; Vietnam Academy of Science and Technology, Institute of Natural Products Chemistry, 18 Hoang Quoc Viet, Cau Giay, 10000, Caugiay, VIET NAM., Hung NH; Duy Tan University, Department of Pharmacy, 03 Quang Trung, 550000, Lienchieu, VIET NAM., Huong VT; Duy Tan University, Department of Pharmacy, 03 Quang Trung, 550000, Lienchieu, VIET NAM., Thuy TTT; Ha Noi Open Univeristy, Institute of Biotechnology and Food Technology, B101 Nguyen Hien, 10000, Hai Ba Trung, VIET NAM., Chung NT; Ha Noi Open University, Institute of Biotechnology and Food Technology, B101 Nguyen Hien, Hai Ba Trung, VIET NAM., Son NT; Vietnam Academy of Science and Technology, Institute of Chemistry, 18 Hoang Quoc Viet, Cau Giay, 10000, Caugiay, VIET NAM., Linh NN; Thanh Do University, Falcuty of Pharmacy, 32 Kim Chung, 10000, Hoai Duc, VIET NAM.
Jazyk: angličtina
Zdroj: Chemistry & biodiversity [Chem Biodivers] 2024 Sep 24, pp. e202401882. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1002/cbdv.202401882
Abstrakt: Chemical constituents from essential oil and n-hexane extract of S hemilamprum leaves were first identified. The obtained essential oil was dominated by monoterpene hydrocarbons (71.55%), and their oxygenated derivatives (20.2%), in which β-pinene (31.5%), limonene (19.4%), α-pinene (12.3%), and α-terpineol (7.4%) were the principal agents. The n-hexane extract was characterized by monoterpene hydrocarbons (42.2%) and non-terpenic compounds (34.0%) with β-pinene (32.8%), and n-hexadecane (10.2%) being the major compounds. Both two samples showed antimicrobial activity against the Gram (+) bacterium Staphylococcus aureus ATCC 6538, the Gram (-) bacterium Pseudomonas aeruginosa ATCC 9027, and the yeast Saccharomyces cerevisiae ATCC 2601 with the same MIC value of 128 µg/mL. Remarkably, they strongly inhibited mosquito larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae with the LC50 and L90 values of less than 20 µg/mL for 24 and 48 h treatments. A molecular docking study suggested limonene and α-terpineol as potent inhibitors of the mosquito odorant binding protein. In silico study on the physicochemical and ADMET properties of the main components of essential oils was also conducted.
(© 2024 Wiley‐VCH GmbH.)
Databáze: MEDLINE
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