Ethical, Legal, and Social Implications of Gene-Environment Interaction Research.

Autor: Calluori S; Columbia Mailman School of Public Health, New York, New York, USA.; Division of Genome Sciences, NHGRI, Bethesda, Maryland, USA., Heimke KK; Genomic Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI, Bethesda, Maryland, USA., Caga-Anan C; Genomic Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI, Bethesda, Maryland, USA., Kaufman D; Division of Genomics and Society, NHGRI, Bethesda, Maryland, USA., Mechanic LE; Genomic Epidemiology Branch, Epidemiology and Genomics Research Program, DCCPS, NCI, Bethesda, Maryland, USA., McAllister KA; Genes, Environment, and Health Branch, Division of Extramural Research and Training, NIEHS, Durham, North Carolina, USA.
Jazyk: angličtina
Zdroj: Genetic epidemiology [Genet Epidemiol] 2024 Sep 24. Date of Electronic Publication: 2024 Sep 24.
DOI: 10.1002/gepi.22591
Abstrakt: Many complex disorders are impacted by the interplay of genetic and environmental factors. In gene-environment interactions (GxE), an individual's genetic and epigenetic makeup impacts the response to environmental exposures. Understanding GxE can impact health at the individual, community, and population levels. The rapid expansion of GxE research in biomedical studies for complex diseases raises many unique ethical, legal, and social implications (ELSIs) that have not been extensively explored and addressed. This review article builds on discussions originating from a workshop held by the National Institute of Environmental Health Sciences (NIEHS) and the National Human Genome Research Institute (NHGRI) in January 2022, entitled: "Ethical, Legal, and Social Implications of Gene-Environment Interaction Research." We expand upon multiple key themes to inform broad recommendations and general guidance for addressing some of the most unique and challenging ELSI in GxE research. Key takeaways include strategies and approaches for establishing sustainable community partnerships, incorporating social determinants of health and environmental justice considerations into GxE research, effectively communicating and translating GxE findings, and addressing privacy and discrimination concerns in all GxE research going forward. Additional guidelines, resources, approaches, training, and capacity building are required to further support innovative GxE research and multidisciplinary GxE research teams.
(© 2024 The Author(s). Genetic Epidemiology published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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