The severity of distal sensory polyneuropathy increasing with HIV/AIDS stage.
| Autor: | Sompa AW; Neurology Department, Faculty of Medicine and Health Sciences, Universitas Muhammadiyah Makassar, Makassar, Indonesia., Goysal Y; Neurology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia., Akbar M; Neurology Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia., Diarfah AD; Faculty of Medical and Health Sciences, UIN Alauddin, Makassar, Indonesia. |
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| Jazyk: | angličtina |
| Zdroj: | The Pan African medical journal [Pan Afr Med J] 2024 Jun 07; Vol. 48, pp. 51. Date of Electronic Publication: 2024 Jun 07 (Print Publication: 2024). |
| DOI: | 10.11604/pamj.2024.48.51.33972 |
| Abstrakt: | Distal sensory polyneuropathy (DSP) is the most common neurological problem in HIV/AIDS Patients. It represents a complex symptom that occurs because of peripheral nerve damage related to advanced HIV disease and in association with the use of antiretroviral therapy. DSP is a frequent symptom in which the specific pathophysiology is not well understood. Recently, mitochondrial toxicity and antiretroviral toxic neuropathies have been more identified as a possible etiology of DSP. This study's objective was to determine factors associated with DSP severity in HIV/AIDS patients. This cross-sectional study was followed by 50 HIV/AIDS outpatients at some hospitals in Makassar, Indonesia who met the inclusion criteria. DSP is diagnosed using non-invasive screening tools subjective peripheral neuropathy screen (SPNS) which can determine the severity of DSP in advance. Some factors were analyzed by using Pearson's chi-square test and Spearman's correlation test. Forty-three participants (86%) had diagnosed DSP which is mostly moderate in severity (48%). Statistical analysis showed significant correlation between HIV/AIDS Stage and DSP severity (p=0.032) meanwhile CD4 count, antiretroviral, body mass index (BMI), and hemoglobin level have no significant correlation to DSP severity. In conclusion, HIV/AIDS stage and DSP severity correlate where the later the stage the more severe DSP. Competing Interests: The authors declare no competing interests. (Copyright: Andi Weri Sompa et al.) |
| Databáze: | MEDLINE |
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