Metal-organic frameworks in drug delivery: engineering versatile platforms for therapeutic applications.
| Autor: | Khafaga DSR; Health Sector, Faculty of Science, Galala University New Galala City 43511 Suez Egypt., El-Morsy MT; Bionanotechnology Department, Faculty of Nanotechnology, Cairo University Giza 12613 Egypt., Faried H; Biotechnology Department, Faculty of Science, Cairo University Giza 12613 Egypt., Diab AH; Biotechnology Department, Faculty of Science, Cairo University Giza 12613 Egypt., Shehab S; Biotechnology Department, Faculty of Science, Cairo University Giza 12613 Egypt., Saleh AM; Bionanotechnology Department, Faculty of Nanotechnology, Cairo University Giza 12613 Egypt., Ali GAM; College of Marine Science and Aquatic Biology, University of Khorfakkan 18119 Sharjah United Arab Emirates gomaa.ali@ukf.ac.ae.; Faculty of Science, Galala University 43511 Suez Egypt gomaasanad@gmail.com gomaasanad@azhar.edu.eg.; Chemistry Department, Faculty of Science, Al-Azhar University Assiut 71524 Egypt. |
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| Jazyk: | angličtina |
| Zdroj: | RSC advances [RSC Adv] 2024 Sep 23; Vol. 14 (41), pp. 30201-30229. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024). |
| DOI: | 10.1039/d4ra04441j |
| Abstrakt: | Recently, metal-organic frameworks (MOFs) have attracted much attention as versatile materials for drug delivery and personalized medicine. MOFs are porous structures made up of metal ions coupled with organic ligands. This review highlights the synthesis techniques used to design MOFs with specific features such as surface area and pore size, and the drug encapsulation within MOFs not only improves their stability and solubility but also allows for controlled release kinetics, which improves therapeutic efficacy and minimizes adverse effects. Furthermore, it discusses the challenges and potential advantages of MOF-based drug delivery, such as MOF stability, biocompatibility, and scale-up production. With further advancements in MOF synthesis, functionalization techniques, and understanding of their interactions using biological systems, MOFs can have significant promise for expanding the area of personalized medicine and improving patient outcomes. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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