Successful treatment of pan-drug resistant Acinetobacter baumannii meningitis/ventriculitis following craniotomy and external ventricular drainage: a case report.

Autor: Gavrilovska AD; University Clinic of Neurosurgery, Clinical Center 'Mother Theresa', 1000 Skopje, Republic of North Macedonia., Veljanovski H; University Clinic of Neurosurgery, Clinical Center 'Mother Theresa', 1000 Skopje, Republic of North Macedonia., Jovchevski R; Institute of Microbiology and Parasitology, Faculty of Medicine, Ss. Cyril and Methodius University in Skopje, 50 Divizija 6, 1000 Skopje, Republic of North Macedonia.
Jazyk: angličtina
Zdroj: Journal of surgical case reports [J Surg Case Rep] 2024 Sep 23; Vol. 2024 (9), pp. rjae603. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI: 10.1093/jscr/rjae603
Abstrakt: Healthcare-associated central nervous system infections are a significant complication for patients undergoing neurosurgical interventions. We present a case of a 6-year-old patient with an embryonal tumor of the central nervous system. Following a craniotomy for the resection of the tumor, an external ventricular drainage was placed. Several weeks after surgery, she developed signs of meningism. Cerebrospinal fluid cultures were positive for pan-drug resistant Acinetobacter baumannii . Several revisions with the insertion of new external valves were done. She was treated with intravenously meropenem and vancomycin combined with colistin administrated intraventricularly. Significant improvement was seen clinically with negative cultures after 2 weeks. The synergistic action of colistin administrated locally combined with systemic antibiotics may be a promising option for critically ill patients with pan-drug resistant A. baumannii central nervous system infection.
Competing Interests: None declared.
(Published by Oxford University Press and JSCR Publishing Ltd. © The Author(s) 2024.)
Databáze: MEDLINE
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