| Autor: |
Gladysheva IP, Sullivan RD, Saleem S, Castellino FJ, Ploplis VA, Reed GL |
| Jazyk: |
angličtina |
| Zdroj: |
BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 12. Date of Electronic Publication: 2024 Sep 12. |
| DOI: |
10.1101/2024.09.06.611753 |
| Abstrakt: |
Symptomatic heart failure (sHF) with cardiac dysfunction, edema, and mortality are driven by overactivation of the renin-angiotensin-aldosterone system (RAAS). Renin is widely recognized as a key initiator of RAAS function, yet the mechanisms that activate renin remain a mystery. We discovered that activated coagulation factor XII generates active renin in the circulation and is directly linked to pathological activation of the systemic RAAS, development of sHF, and increased mortality. These findings suggest a new paradigm for therapeutically modulating the RAAS in sHF and other pathological conditions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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