Variation in moment-to-moment brain state engagement changes across development and contributes to individual differences in executive function.

Autor: Ye J; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut., Tejavibulya L; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut., Dai W; Department of Biostatistics, Yale School of Public Health, New Haven, Connecticut., Cope LM; Department of Psychiatry and Addiction Center, University of Michigan, Ann Arbor, Michigan., Hardee JE; Department of Psychiatry and Addiction Center, University of Michigan, Ann Arbor, Michigan., Heitzeg MM; Department of Psychiatry and Addiction Center, University of Michigan, Ann Arbor, Michigan., Lichenstein S; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut., Yip SW; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.; Child Study Center, Yale School of Medicine, New Haven, Connecticut., Banaschewski T; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Germany., Baker GJ; Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom., Bokde ALW; Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland., Brühl R; Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany., Desrivières S; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, United Kingdom., Flor H; Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany., Gowland P; Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, United Kingdom., Grigis A; NeuroSpin, CEA, Université Paris-Saclay, F-91191 Gif-sur-Yvette, France., Heinz A; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.; German Center for Mental Health (DZPG), site Berlin-Potsdam., Martinot JL; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 'Trajectoires développementales & psychiatrie', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, France., Paillère Martinot ML; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 'Trajectoires développementales & psychiatrie', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, France.; AP-HP. Sorbonne Université, Department of Child and Adolescent Psychiatry, Pitié-Salpêtrière Hospital, Paris, France., Artiges E; Institut National de la Santé et de la Recherche Médicale, INSERM U A10 'Trajectoires développementales & psychiatrie', University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, France.; Psychiatry Department, EPS Barthélémy Durand, Etampes; France., Nees F; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Germany.; Institute of Medical Psychology and Medical Sociology, University Medical Center Schleswig-Holstein, Kiel University, Kiel, Germany., Orfanos DP; Department of Psychology, School of Social Sciences, University of Mannheim, 68131 Mannheim, Germany., Poustka L; Department of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany., Hohmann S; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Germany., Holz N; Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159 Mannheim, Germany; German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Germany., Baeuchl C; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany., Smolka MN; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany., Vaidya N; Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Germany., Walter H; Department of Psychiatry and Psychotherapy CCM, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany., Whelan R; School of Psychology and Global Brain Health Institute, Trinity College Dublin, Ireland., Schumann G; German Center for Mental Health (DZPG), site Berlin-Potsdam.; Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.; Centre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China., Garavan H; Department of Psychiatry, University of Vermont, Burlington, Vermont.; Department of Psychology, University of Vermont, Burlington, Vermont., Chaarani B; Department of Psychiatry, University of Vermont, Burlington, Vermont., Gee DG; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.; Child Study Center, Yale School of Medicine, New Haven, Connecticut.; Department of Psychology, Yale University, New Haven, Connecticut., Baskin-Sommers A; Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut.; Department of Psychology, Yale University, New Haven, Connecticut., Casey BJ; Department of Neuroscience and Behavior, Barnard College-Columbia University, New York, New York., Scheinost D; Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut.; Child Study Center, Yale School of Medicine, New Haven, Connecticut.; Department of Radiology & Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.; Department of Biomedical Engineering, Yale University, New Haven, Connecticut.; Department of Statistics & Data Science, Yale University, New Haven, Connecticut.
Jazyk: angličtina
Zdroj: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 11. Date of Electronic Publication: 2024 Sep 11.
DOI: 10.1101/2024.09.06.611627
Abstrakt: Neural variability, or variation in brain signals, facilitates dynamic brain responses to ongoing demands. This flexibility is important during development from childhood to young adulthood, a period characterized by rapid changes in experience. However, little is known about how variability in the engagement of recurring brain states changes during development. Such investigations would require the continuous assessment of multiple brain states concurrently. Here, we leverage a new computational framework to study state engagement variability (SEV) during development. A consistent pattern of SEV changing with age was identified across cross-sectional and longitudinal datasets (N>3000). SEV developmental trajectories stabilize around mid-adolescence, with timing varying by sex and brain state. SEV successfully predicts executive function (EF) in youths from an independent dataset. Worse EF is further linked to alterations in SEV development. These converging findings suggest SEV changes over development, allowing individuals to flexibly recruit various brain states to meet evolving needs.
Databáze: MEDLINE