Early Life Neuroimaging: The Generalizability of Cortical Area Parcellations Across Development.

Autor:	Tu JC; Department of Radiology, Washington University in St. Louis., Myers M; Department of Psychiatry, Washington University in St. Louis., Li W; Department of Mathematics and Statistics, Washington University in St. Louis., Li J; Department of Mathematics and Statistics, Washington University in St. Louis.; Department of Statistics, University of Chicago., Wang X; Department of Radiology, Washington University in St. Louis., Dierker D; Department of Radiology, Washington University in St. Louis., Day TKM; Masonic Institute for the Developing Brain, University of Minnesota.; Institute of Child Development, University of Minnesota.; Center for Brain Plasticity and Recovery, Georgetown University., Snyder AZ; Department of Radiology, Washington University in St. Louis., Latham A; Department of Neurology, Washington University in St. Louis., Kenley JK; Department of Neurology, Washington University in St. Louis., Sobolewski CM; Department of Radiology, Washington University in St. Louis.; Department of Psychology, Virginia Commonwealth University., Wang Y; Department of Mathematics and Statistics, Washington University in St. Louis., Labonte AK; Department of Psychiatry, Washington University in St. Louis., Feczko E; Masonic Institute for the Developing Brain, University of Minnesota., Kardan O; Department of Psychiatry, University of Michigan., Moore LA; Masonic Institute for the Developing Brain, University of Minnesota., Sylvester CM; Department of Psychiatry, Washington University in St. Louis., Fair DA; Masonic Institute for the Developing Brain, University of Minnesota.; Institute of Child Development, University of Minnesota., Elison JT; Masonic Institute for the Developing Brain, University of Minnesota.; Institute of Child Development, University of Minnesota., Warner BB; Department of Pediatrics, Washington University in St. Louis., Barch DM; Department of Psychological and Brain Sciences, Washington University in St Louis., Rogers CE; Department of Psychiatry, Washington University in St. Louis., Luby JL; Department of Psychiatry, Washington University in St. Louis., Smyser CD; Department of Radiology, Washington University in St. Louis.; Department of Psychiatry, Washington University in St. Louis.; Department of Neurology, Washington University in St. Louis.; Department of Pediatrics, Washington University in St. Louis., Gordon EM; Department of Radiology, Washington University in St. Louis., Laumann TO; Department of Radiology, Washington University in St. Louis., Eggebrecht AT; Department of Radiology, Washington University in St. Louis., Wheelock MD; Department of Radiology, Washington University in St. Louis.
Jazyk:	angličtina
Zdroj:	BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 11. Date of Electronic Publication: 2024 Sep 11.
DOI:	10.1101/2024.09.09.612056
Abstrakt:	The cerebral cortex comprises discrete cortical areas that form during development. Accurate area parcellation in neuroimaging studies enhances statistical power and comparability across studies. The formation of cortical areas is influenced by intrinsic embryonic patterning as well as extrinsic inputs, particularly through postnatal exposure. Given the substantial changes in brain volume, microstructure, and functional connectivity during the first years of life, we hypothesized that cortical areas in 1-to-3-year-olds would exhibit major differences from those in neonates and progressively resemble adults as development progresses. Here, we parcellated the cerebral cortex into putative areas using local functional connectivity gradients in 92 toddlers at 2 years old. We demonstrated high reproducibility of these cortical regions across 1-to-3-year-olds in two independent datasets. The area boundaries in 1-to-3-year-olds were more similar to adults than neonates. While the age-specific group parcellation fitted better to the underlying functional connectivity in individuals during the first 3 years, adult area parcellations might still have some utility in developmental studies, especially in children older than 6 years. Additionally, we provided connectivity-based community assignments of the parcels, showing fragmented anterior and posterior components based on the strongest connectivity, yet alignment with adult systems when weaker connectivity was included. Competing Interests: Declaration of Competing Interests The authors declared no competing interests directly related to this manuscript.
Databáze:	MEDLINE
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