Food Consumption and Risk of Islet Autoimmunity and Type 1 Diabetes in Children at Increased Genetic Susceptibility for Type 1 Diabetes.

Autor:	Virtanen SM; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland. Electronic address: suvi.virtanen@thl.fi., Peltonen EJ; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland., Hakola L; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Niinistö S; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Takkinen HM; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Ahonen S; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Åkerlund M; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Uusitalo U; Health Informatics Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States., Mattila M; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Salo TE; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland; Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland., Ilonen J; Institute of Biomedicine, Immunogenetics Laboratory, University of Turku, Turku, Finland., Toppari J; Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland., Veijola R; Department of Paediatrics, Research Unit of Clinical Medicine, Medical Research Centre, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland., Knip M; Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland., Nevalainen J; Unit of Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.
Jazyk:	angličtina
Zdroj:	The Journal of nutrition [J Nutr] 2024 Nov; Vol. 154 (11), pp. 3465-3474. Date of Electronic Publication: 2024 Sep 21.
DOI:	10.1016/j.tjnut.2024.09.018
Abstrakt:	Background: Prospective longitudinal evidence considering the entire childhood food consumption in relation to the development of islet autoimmunity (IA or) type 1 diabetes is lacking. Objectives: We studied the associations of consumption of various foods and their combinations with IA and type 1 diabetes risk. Methods: Children with genetic susceptibility to type 1 diabetes born in 1996-2004 were followed from birth up to ≤6 y of age in the prospective birth cohort type 1 diabetes prediction and prevention study (n = 5674). Exposure variables included 34 food groups covering the entire diet based on repeated 3-d food records at ages 3 mo to 6 y. Endpoints were islet cell antibodies plus biochemical IA (n = 247), multiple biochemical IA (n = 206), and type 1 diabetes (n = 94). We analyzed associations between longitudinally observed foods and risk of IA/type 1 diabetes using a Bayesian approach to joint models in 1-food and multi-food models adjusted for energy intake, sex, human leukocyte antigen genotype, and familial diabetes. Results: The final multi-food model for islet cell antibodies plus biochemical IA included oats [hazard ratio (HR): 1.09; 95% credible interval (CI): 1.04, 1.14], banana (HR: 1.07; 95% CI: 1.03, 1.11), and cruciferous vegetables (HR: 0.83; 95% CI: 0.73, 0.94). The final model for multiple biochemical IA included, in addition to the above-mentioned foods, fermented dairy (HR: 1.42; 95% CI: 1.12, 1.78) and wheat (HR: 1.10; 95% CI: 1.03, 1.18). The final multi-food model for type 1 diabetes included rye (HR: 1.27; 95% CI: 1.07, 1.50), oats (HR: 1.15; 95% CI: 1.03, 1.26), fruits (HR: 1.05; 95% CI: 1.01, 1.09), and berries (HR: 0.67; 95% CI: 0.50, 0.93). Conclusions: Higher consumption of oats, gluten-containing cereals, and fruits was associated with increased that of cruciferous vegetables with decreased risk of several type 1 diabetes-related endpoints when considering all the foods in combination. Further etiological and mechanistic studies are warranted. Competing Interests: Conflict of interest The authors report no conflicts of interest. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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