Preparation, characterization, and binding mechanism of quercetin-loaded composite nanoparticles based on zein-soybean protein isolate.

Autor: Sun Z; College of Food Science, Northeast Agricultural University, Harbin 150030, China., Li D; Heilongjiang Green Food Science Research Institute, Harbin 150028, China., Lin P; College of Food Science, Northeast Agricultural University, Harbin 150030, China., Zhao Y; College of Food Science, Northeast Agricultural University, Harbin 150030, China., Zhang J; College of Food Science, Northeast Agricultural University, Harbin 150030, China., Sergeeva I; Heilongjiang Province China-Mongolia-Russia Joint R&D Laboratory for Bio-processing and Equipment for Agricultural Products (International Cooperation), Department of Food Science, Northeast Agricultural University, Harbin 150030, China; Department of Plant-Based Food Technology, Kemerovo State University, Kemerovo 650000, Russia., Li Y; College of Food Science, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Province China-Mongolia-Russia Joint R&D Laboratory for Bio-processing and Equipment for Agricultural Products (International Cooperation), Department of Food Science, Northeast Agricultural University, Harbin 150030, China. Electronic address: yangli@neau.edu.cn., Zheng H; College of Food Science, Northeast Agricultural University, Harbin 150030, China; Heilongjiang Green Food Science Research Institute, Harbin 150028, China; Heilongjiang Province China-Mongolia-Russia Joint R&D Laboratory for Bio-processing and Equipment for Agricultural Products (International Cooperation), Department of Food Science, Northeast Agricultural University, Harbin 150030, China. Electronic address: zhenghuanyu1@163.com.
Jazyk: angličtina
Zdroj: Food chemistry [Food Chem] 2025 Jan 15; Vol. 463 (Pt 3), pp. 141359. Date of Electronic Publication: 2024 Sep 18.
DOI: 10.1016/j.foodchem.2024.141359
Abstrakt: In this study, quercetin (Que) was encapsulated for controlled release during gastrointestinal digestion using zein-soy isolate protein (SPI) composite nanoparticles that were made following an antisolvent precipitation technique. The average particle size of the composite nanoparticles ranged from 182.1 to 230.9 nm, and the polydispersity index (PDI) was small (0.105-0.323). The microstructure revealed that the composite nanoparticles were spherically distributed and that Que. was embedded on the surface of the nanoparticles. Que. has an encapsulation efficiency of up to 93.3 %. Spectrum analysis, molecular docking and zeta potential measurements revealed that the interactions between the composite nanoparticles and Que. occurred mainly through hydrophobic interactions, hydrogen bonding, and electrostatic interactions. Compared with single zein nanoparticles, the composite nanoparticles showed a significant and controlled release of Que. during the whole simulated gastrointestinal digestion process. This study provides a novel method for the development of a controlled-release drug delivery system for controlling the release of Que.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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