Ethosuximide-loaded bismuth ferrite nanoparticles as a potential drug delivery system for the treatment of epilepsy disease.

Autor: Guldorum Y; Department of Biomedical Engineering, Electrical and Electronics Faculty, Yıldız Technical University, Istanbul, Turkey.; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey., Ayran M; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Institute of Pure and Applied Sciences, Metallurgical and Materials Engineering, Marmara University, Istanbul, Turkey., Bulut B; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey., Ilgar S; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yildiz Technical University, Istanbul, Turkey., Ulag S; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Kanli Z; Department of Biophysics, School of Medicine, Marmara University, Istanbul, Turkey., Aydin B; Department of Biophysics, School of Medicine, Marmara University, Istanbul, Turkey., Gulhan R; Department of Medical Pharmacology, School of Medicine, Marmara University, Istanbul, Turkey.; Epilepsy Research and Implementation Center, Marmara University, Istanbul, Turkey., Bedir T; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Gunduz O; Center for Nanotechnology & Biomaterials Application and Research (NBUAM), Marmara University, Istanbul, Turkey.; Department of Metallurgical and Materials Engineering, Faculty of Technology, Marmara University, Istanbul, Turkey., Narayan RJ; Joint Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC, United States of America.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2024 Sep 23; Vol. 19 (9), pp. e0305335. Date of Electronic Publication: 2024 Sep 23 (Print Publication: 2024).
DOI: 10.1371/journal.pone.0305335
Abstrakt: Encapsulating antiepileptic drugs (AEDs), including ethosuximide (Etho), into nanoparticles shows promise in treating epilepsy. Nanomedicine may be the most significant contributor to addressing this issue. It presents several advantages compared to traditional drug delivery methods and is currently a prominent area of focus in cancer research. Incorporating Etho into bismuth ferrite (BFO) nanoparticles within diverse controlled drug delivery systems is explored to enhance drug efficacy. This approach is primarily desired to aid in targeted drug delivery to the brain's deepest regions while limiting transplacental permeability, reducing fetal exposure, and mitigating associated adverse effects. In this investigation, we explored Etho, an antiepileptic drug commonly employed for treating absence seizures, as the active ingredient in BFO nanoparticles at varying concentrations (10 and 15 mg). Characterization of the drug-containing BFO nanoparticles involved scanning electron microscopy (SEM) and elemental analysis. The thermal properties of the drug-containing BFO nanoparticles were evaluated via differential scanning calorimetry (DSC) analysis. Cytotoxicity evaluations using the MTT assay were conducted on all nanoparticles, and human neuroblastoma cell line cultures (SH-SY5Y) were treated with each particle over multiple time intervals. Cell viability remained at 135% after 7 days when exposed to 15 mg of Etho in BFO nanoparticles. Additionally, in vitro drug release kinetics for Etho revealed sustained release lasting up to 5 hours with a drug concentration of 15 mg.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Guldorum et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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