Bone Accrual Trajectories in Children and Adolescents with Perinatal HIV Infection.

Autor:	DiMeglio LA; Division of Pediatric Endocrinology and Diabetology, Department of Pediatrics, Riley Hospital for Children at IU Health, Indiana University School of Medicine, Indianapolis, IN  USA., Yu W; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA., Kalkwarf HJ; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH  USA., Brummel S; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA., Chen JS; Department of Pediatrics, Drexel University College of Medicine, Philadelphia, PA  USA., Geffner ME; The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine of USC, Los Angeles, CA  USA., McFarland EJ; Department of Pediatric Infectious Diseases, University of Colorado School of Medicine, Aurora, CO  USA., Mirza A; Division of Pediatric Infectious Diseases, University of Florida, Jacksonville, FL  USA., Patel K; Department of Epidemiology, Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA., Shiau S; Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ  USA., Jacobson DL; Center for Biostatistics in AIDS Research, Harvard T.H. Chan School of Public Health, Boston, MA  USA.
Jazyk:	angličtina
Zdroj:	The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Sep 23. Date of Electronic Publication: 2024 Sep 23.
DOI:	10.1210/clinem/dgae631
Abstrakt:	Context: Low bone mineral density (BMD) has been reported in children and adolescents living with perinatally-acquired HIV (PHIV). Little is known about their bone accrual through puberty compared to an uninfected healthy cohort. Objective: To compare bone accrual in PHIV and healthy children. Design: PHIV children aged 7-16 years had dual energy X-ray absorptiometry (DXA) at entry, 2 years, and then at least 2 years later. Bone accrual was compared to healthy children from the Bone Mineral Density in Childhood Study (BMDCS). Setting: United States academic clinical research centers. Patients: 172 PHIV; 1321 BMDCS. Analysis: We calculated height-adjusted whole-body and spine BMD and bone mineral content (BMC) Z-scores in PHIV using BMDCS reference curves. We fit piecewise weighted linear mixed effects models with change points at 11 and 15 years, adjusted for age, sex, race, height Z-score, and Tanner stage, to compare BMD and BMC Z-scores across actual age by cohort.Main Outcome Measure: BMD/BMC Z-scores. Results: Height-adjusted whole-body BMD and BMC Z-scores in PHIV were lower across age compared to BMDCS children. Spine BMD Z-score across age was higher in PHIV after height adjustment. Whole-body and spine bone area tended to be lower in PHIV. PHIV had slower accrual in whole-body and spine bone area before 14 years. After 15 years, bone area accruals were similar, as were height-adjusted spine BMC Z-scores, across age. Conclusions: PHIV had persistent deficits in all measures except height-adjusted spine BMD and BMC Z-scores. Data are needed on PHIV followed to adulthood. (© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com. See the journal About page for additional terms.)
Databáze:	MEDLINE
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