Novel approaches of mycosynthesized zinc oxide nanoparticles (ZnONPs) using Pleurotus sajor-caju extract and their biological and environmental applications.

Autor: Manimaran K; Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), JI. Raya Bogor Km. 46, Cibinong, 16911, Indonesia. manimaran.kumar@brin.go.id., Yanto DHY; Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), JI. Raya Bogor Km. 46, Cibinong, 16911, Indonesia. dede.heri.yuli.yanto@brin.go.id., Sari IP; Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), JI. Raya Bogor Km. 46, Cibinong, 16911, Indonesia., Karimah SN; Research Center for Applied Microbiology, National Research and Innovation Agency (BRIN), JI. Raya Bogor Km. 46, Cibinong, 16911, Indonesia., Kamaraj C; Interdisciplinary Institute of Indian System of Medicine (IIISM), Directorate of Research and Virtual Education, SRM Institute of Science and Technology (SRMIST), Kattankulathur, Chennai, Tamil Nadu, 603 203, India., Manoharadas S; Department of Botany and Microbiology, College of Science, King Saud University, P.O. BOX 2454, Riyadh, Saudi Arabia., Praburaman L; Centre for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University (Deemed to be University), Chennai, Tamil Nadu, India., Suganthi S; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea. suganthichempower@gmail.com., Oh TH; School of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan, 38541, Republic of Korea. taehwanoh@ynu.ac.kr.
Jazyk: angličtina
Zdroj: Environmental geochemistry and health [Environ Geochem Health] 2024 Sep 23; Vol. 46 (10), pp. 423. Date of Electronic Publication: 2024 Sep 23.
DOI: 10.1007/s10653-024-02185-y
Abstrakt: In this study, mycosynthesized zinc oxide nanoparticles (ZnONPs) are fabricated via Pleurotus sajor-caju mushroom extract, and their potential medical and environmental applications are demonstrated. The biosynthesized ZnONPs were assessed for their antibacterial, anticancer, and biodecolorization potential efficiency. They were also characterized and morphologically analyzed by UV-visible spectroscopy, XRD, FT-IR, FE-SEM, EDX, HR-TEM, Zeta potential, and GC-MS analysis. The UV visible spectrum analysis of synthesized ZnONPs analyzed outcome 354 nm was the SPR peak that the nanoparticles displayed. The characteristic Zn-O bond was indicated by a strong peak in the FT-IR study at 432.05 cm -1 . Based on XRD analysis, P. sajor-caju mediated ZnONPs were crystalline nature, with an average nano particle size of 14.21 nm and a polydispersity directory of 0.29. The nanoparticles exhibit modest constancy, as shown by their zeta potential value of - 33.2 mV. The presence of oxygen and zinc was verified by EDX analysis. The ZnONPs were found to be spherical in shape and crystalline nature structure, with smooth surface morphology and a mean particle size of 10 nm using HR-TEM and SAED analysis. The significant antibacterial activity against S. aureus (6.2 ± 0.1), S. mutans (5.4 ± 0.4), and B. subtilis (5.2 ± 0.1 mm) was demonstrated by the synthesized ZnONPs made using mushroom extract. It was discovered that when the concentration of mushroom extract was increased together with synthesized ZnONPs, the bactericidal activity increased considerably. A higher concentration of ZnONPs demonstrated superior antibacterial activity across the ZnONPs ratio tests. The in vitro cytotoxicity assay showed that ZnONPs, even at low doses, had a substantial number of cytotoxic effects on liver cancer cells (LC 50 values 47.42 µg/mL). The effectiveness test revealed that acid blue 129 was degraded. The best decolorization of acid blue 129 at 72.57% after 3 h of soaking serves as evidence for the theory that myco-synthesized ZnONPs by P. sajor-caju mushroom can function as catalysts in reducing the dye. The mycosynthesized ZnONPs from P. sajor-caju extract, and its potential for antibacterial, anticancer, and decolorization are in this investigation. The mycosynthesized ZnONPs suggest a novel use for nanoparticles in the creation of environmental and medicinal products.
(© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
Databáze: MEDLINE
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