Incidence of Kawasaki disease among children in Chandigarh, India during 2015-2019: a trend analysis.

Autor:	Pilania RK; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Basu S; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Dixit J; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Kumrah R; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Jindal AK; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Thangaraj A; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Nimesh R; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Kaur T; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Vignesh P; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Suri D; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Rawat A; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Naganur SH; Department of Cardiology, Advanced Cardiac Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Singhal M; Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Prinja S; Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India., Singh S; Pediatric Allergy and Immunology Unit, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education & Research (PGIMER), Chandigarh, India.
Jazyk:	angličtina
Zdroj:	The Lancet regional health. Southeast Asia [Lancet Reg Health Southeast Asia] 2024 Sep 10; Vol. 29, pp. 100474. Date of Electronic Publication: 2024 Sep 10 (Print Publication: 2024).
DOI:	10.1016/j.lansea.2024.100474
Abstrakt:	Background: Only limited information exists regarding the epidemiology of Kawasaki disease (KD) in low-income and middle-income countries. The present study provides the incidence of KD during 2015-2019 in Chandigarh, north India. Our centre follows the largest KD cohort in India. Methods: Children with KD at Chandigarh diagnosed during January 2015-December 2019 were enrolled in the study. Annual incidence rates were determined using decadal growth rates of the National Census 2011. We computed the incidence of KD in children aged <5, and <15 years. We also undertook linear trend analysis using our incidence data from 1994 to 2019. Findings: During 2015-2019, 83 patients (66 males, 17 females) were diagnosed with KD in Chandigarh. Incidence rates during these 5 years were 5.64, 9.25, 9.11, 9.87, and 9.72/100,000 in children aged <5 years, and 2.65, 4.44, 3.86, 5.07, 4.74/100,000 in children aged <15 years. The median age at diagnosis was 48 months (range: 12 days to 15 years). Compared to previous data (2009-2014), there was a 53.1% increase in annual incidence of KD in children aged <5 years, and a 53.7% increase in children aged <15 years. Coronary artery abnormalities during acute phase were noted in 16.9%, and in 7.2% of patients at 6 weeks of follow-up. The trend analysis indicated a monthly rise of 0.002 cases per 100,000 children aged <5 years, and 0.0165 cases per 100,000 children aged <15 years. Interpretation: The incidence of KD has continued to show an upward trend in Chandigarh over the period 2015-2019. This may indicate a true rise in the occurrence of KD or may reflect better disease ascertainment as a result of greater awareness about KD amongst healthcare professionals. Funding: None. Competing Interests: All authors declare that they have no potential conflicts of interest. (© 2024 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu