A Tetrad Catastrophe: Paraneoplastic Syndrome With Abducens Palsy, Intracranial Hypertension, and Optic Neuropathy in Primary Lung Cancer.

Autor:	Chandran V; Ophthalmology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, MYS.; Ophthalmology, Hospital Kuala Lumpur, Ministry of Health Malaysia, Kuala Lumpur, MYS., Masnon NA; Ophthalmology, Kuala Lumpur Hospital, Kuala Lumpur, MYS., Nasaruddin RA; Ophthalmology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, MYS., Che Hamzah J; Ophthalmology, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, MYS., Mohmood A; Ophthalmology, Hospital Sultan Abdul Aziz Shah, University of Putra Malaysia, Kuala Lumpur, MYS., Abdul Aziz AF; Nuclear Medicine, National Cancer Institute, Putrajaya, MYS.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Aug 20; Vol. 16 (8), pp. e67335. Date of Electronic Publication: 2024 Aug 20 (Print Publication: 2024).
DOI:	10.7759/cureus.67335
Abstrakt:	We report a unique case of paraneoplastic syndrome (PS) associated with primary lung cancer. A 57-year-old woman experienced headaches and bilateral visual loss one month after the onset of isolated right abducens palsy. Examination revealed bilateral poor visual acuity (VA), papilledema, and persistent right abducens palsy. Neuroimaging was normal. Lumbar puncture revealed high cerebrospinal fluid (CSF) opening pressure and protein levels. She was started on acetazolamide and pulse methylprednisolone followed by oral corticosteroids. Her abducens nerve palsy resolved, but her VA deteriorated. Anti-Hu and anti-CV2 were positive. A positron emission tomography (PET) scan revealed primary lung cancer, and she died six months after her initial presentation. This case demonstrated that PS poses a diagnostic challenge and may be associated with poor prognosis. Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Chandran et al.)
Databáze:	MEDLINE
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