A Giant Basal-Cell Carcinoma: A Rare Subtype at a Rare Site.

Autor: Chandanwale SS; Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India., Singh M; Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India., Raj A; Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India., Viswanathan V; Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India., Bharadwaj S; Department of Pathology, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India.
Jazyk: angličtina
Zdroj: International journal of applied & basic medical research [Int J Appl Basic Med Res] 2024 Jul-Sep; Vol. 14 (3), pp. 202-204. Date of Electronic Publication: 2024 Aug 24.
DOI: 10.4103/ijabmr.ijabmr_488_23
Abstrakt: Giant basal-cell carcinoma (BCC) is a rare subtype of BCC which is characterized by aggressive biological behavior with extensive local invasion, frequent metastasis, and poor prognosis. It arises almost exclusively on hair-bearing skin. It has been rarely reported on sole. Various pathogenic factors such as arsenic exposure, ionizing radiation, repeated trauma, and hereditary syndromes have been implicated. A combination of optical coherence tomography and reflectance confocal microscopy can provide useful information for both depth and horizontal extension of tumor and could be used before surgery to explore subclinical extension. Wide local excision of the lesion with histologically confirmed negative margins for the reconstruction of the defect, followed by adjuvant chemoradiation gives a better outcome compared to radiotherapy or chemotherapy alone. Chemotherapy with cisplatin-based treatment is the most common regimen. We report a case of giant BCC on the sole in an elderly male. After excision, the defect was treated with skin grafting.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2024 International Journal of Applied and Basic Medical Research.)
Databáze: MEDLINE
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