Integrating Audiovisual Immersion Into Pediatric Radiation Therapy Across Multiple Centers: Methodology, Timeliness, and Cost of the Audiovisual-Assisted Therapeutic Ambience in Radiation Therapy Prospective Multi-Institutional Trial.

Autor:	Oh J; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.; Department of Radiation Oncology, BC Cancer - Vancouver, Vancouver, BC, Canada., Skinner L; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Gutkin PM; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.; Medical College of Wisconsin, Wauwatosa, Wisconsin., Jiang A; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Donaldson SS; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Loo BW Jr; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Wang YP; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Ewongwo A; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Bredfeldt JS; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Breneman JC; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio., Constine LS; Department of Radiation Oncology and Pediatrics, James P. Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York., Faught AM; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Haas-Kogan D; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Holmes JA; Department of Radiation Oncology, Indiana University School of Medicine, Indianapolis, Indiana., Krasin M; Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Larkin C; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, Ohio., Marcus KJ; Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Maxim PG; Department of Radiation Oncology, University of California Irvine, Irvine, California., McClelland S 3rd; Departments of Radiation Oncology and Neurological Surgery, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio., Murphy B; Department of Radiation Medicine, Oregon Health and Science University, Portland, Oregon., Palmer JD; Department of Radiation Oncology, Ohio State University School of Medicine, Columbus, Ohio., Perkins SM; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, Missouri., Shen CJ; Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, North Carolina., Terezakis S; Department of Radiation Oncology, University of Minnesota School of Medicine, Minneapolis, Minnesota., Bush K; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California., Hiniker SM; Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California.
Jazyk:	angličtina
Zdroj:	Advances in radiation oncology [Adv Radiat Oncol] 2024 Aug 10; Vol. 9 (10), pp. 101589. Date of Electronic Publication: 2024 Aug 10 (Print Publication: 2024).
DOI:	10.1016/j.adro.2024.101589
Abstrakt:	Purpose: The Audiovisual-Assisted Therapeutic Ambience in Radiotherapy (AVATAR) trial was a prospective multicenter study (NCT03991156) examining the combination of video immersion with radiation therapy and was successfully conducted through the collaboration of pediatric radiation oncology teams at 10 institutions independent of any pre-existing consortium. We sought to analyze and report the methodology of trial conception and development, process map, and cost. Methods and Materials: The study enrolled patients aged 3 to 10 years preparing to undergo radiation therapy, integrated the combination of AVATAR-based video immersion with radiation therapy at each institution, and offered AVATAR use as an alternative to anesthesia, with rates of anesthesia use and outcomes of serial standardized anxiety and quality-of-life assessments assessed among the 81 children enrolled. A process map was created based on the trial timeline with the following components: study development time (time from conception of the trial to the accrual of the first patient, including design phase, agreement and approval phase, and site preparation phase), and accrual duration time (time from the first to last accrual). Costs and institutional success rates were calculated. Results: Time from inception of study to last accrual was 3.6 years (1313 days). The study development time was 417 days (31.7%), and accrual duration time was 896 days (68.3%), with the final 50% of accrual occurring in <6 months. Equipment cost was approximately $550 per institution and was covered by funding from the lead study institution. All 10 centers were successful with AVATAR implementation, defined as ≥50% of patients able to avoid anesthesia with the use of AVATAR, including centers with both photon and proton therapy. Conclusions: This report elaborates on the methodology and timeline of trial conception and development using data from a previously published supportive care study combining video immersion with radiation therapy among 10 cooperating pediatric oncology institutions. It highlights the potential for multicenter collaborations on prospective trials integrating supportive care therapies with radiation therapy. (© 2024 The Author(s).)
Databáze:	MEDLINE
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