Outdoor nighttime light exposure (light pollution) is associated with Alzheimer's disease.

Autor:	Voigt RM; Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, United States.; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.; Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, United States., Ouyang B; Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, United States., Keshavarzian A; Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, United States.; Department of Internal Medicine, Rush University Medical Center, Chicago, IL, United States.; Department of Anatomy and Cell Biology, Rush University Medical Center, Chicago, IL, United States.; Department of Physiology, Rush University Medical Center, Chicago, IL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in neuroscience [Front Neurosci] 2024 Sep 06; Vol. 18, pp. 1378498. Date of Electronic Publication: 2024 Sep 06 (Print Publication: 2024).
DOI:	10.3389/fnins.2024.1378498
Abstrakt:	Introduction: Alzheimer's disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. Exposure to artificial light at night is one environmental factor that may influence AD. Methods: This study evaluated the relationship between outdoor nighttime light exposure and AD prevalence in the United States using satellite acquired outdoor nighttime light intensity and Medicare data. Results: Higher outdoor nighttime light was associated with higher prevalence of AD. While atrial fibrillation, diabetes, hyperlipidemia, hypertension, and stroke were associated more strongly with AD prevalence than nighttime light intensity, nighttime light was more strongly associated with AD prevalence than alcohol abuse, chronic kidney disease, depression, heart failure, and obesity. Startlingly, nighttime light exposure more strongly associated with AD prevalence in those under the age of 65 than any other disease factor examined. Discussion: These data suggest light exposure at night may influence AD, but additional studies are needed. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 Voigt, Ouyang and Keshavarzian.)
Databáze:	MEDLINE
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