Molecular farming expression of recombinant fusion proteins applied to skincare strategies.
| Autor: | Yu G; College of Life and Environmental Sciences, Wenzhou University, Wen Zhou, China., Zhao W; College of Life and Environmental Sciences, Wenzhou University, Wen Zhou, China., Wang Y; Jilin Academy of Agricultural Sciences, Northeast Innovation Center of China Agricultural Science and Technology, Ji Lin, China., Xu N; College of Life and Environmental Sciences, Wenzhou University, Wen Zhou, China. |
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| Jazyk: | angličtina |
| Zdroj: | PeerJ [PeerJ] 2024 Sep 18; Vol. 12, pp. e17957. Date of Electronic Publication: 2024 Sep 18 (Print Publication: 2024). |
| DOI: | 10.7717/peerj.17957 |
| Abstrakt: | This review discusses the current research progress in molecular farming technology in the field of skincare, with an emphasis on molecular farming expression strategies. The strategies of transdermal drug delivery and their advantages are also highlighted. The expression of cosmetically relevant fused proteins has become an important way to enhance the efficacy of the proteins. Therefore, we also discuss the feasibility and strategies for expressing fusion proteins in A. thaliana , specifically the fusion of Epidermal growth factor (EGF) to a cell-penetrating peptide (CPP), in which the production can be greatly enhanced via plant expression systems since these systems offer higher biosecurity, flexibility, and expansibility than prokaryotic, animal and mammalian expression systems. While the fusion of EGF to CCP can enhance its transdermal ability, the effects of the fusion protein on skin repair, melasma, whitening, and anti-aging are poorly explored. Beyond this, fusing proteins with transdermal peptides presents multiple possibilities for the development of tissue repair and regeneration therapeutics, as well as cosmetics and beauty products. As certain plant extracts are known to contain proteins beneficial for skin health, the expression of these proteins in plant systems will better maintain their integrity and biological activities, thereby facilitating the development of more effective skincare products. Competing Interests: The authors declare that they have no competing interests. (© 2024 Yu et al.) |
| Databáze: | MEDLINE |
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