The relationship between mindfulness and empathy with the oxytocinergic system in persons with schizophrenia spectrum disorders - A proof-of-concept randomized controlled trial (OXYGEN).

Autor:	Böge K; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany.; German Mental Health Center (DZPG), Germany., Bergmann N; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany., Zierhut M; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany., Hahne I; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany., Braun A; Department of Psychiatry and Neuroscience, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany., Kraft J; Department of Psychiatry and Neuroscience, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany., Conell I; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany., Ta TMT; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany., Thomas N; Centre for Mental Health, Swinburne University of Technology, Melbourne, Australia., Chadwick P; Department of Psychology, University of Bath, Bath, UK., Ripke S; Department of Psychiatry and Neuroscience, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Germany.; Stanley Center for Psychiatric Research at Broad Institute of MIT and Harvard, Cambridge, MA, USA.; German Mental Health Center (DZPG), Germany., Hahn E; Department of Psychiatry and Neuroscience, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, Germany.
Jazyk:	angličtina
Zdroj:	International journal of clinical and health psychology : IJCHP [Int J Clin Health Psychol] 2024 Jul-Sep; Vol. 24 (3), pp. 100503. Date of Electronic Publication: 2024 Sep 10.
DOI:	10.1016/j.ijchp.2024.100503
Abstrakt:	Background: The present study explored the feasibility and acceptability as well as the impact of mindfulness-based group therapy (MBGT) on oxytocin levels (OXT) and clinical parameters in outpatients with schizophrenia spectrum disorders (SSD). Methods: In a randomized-controlled design, outpatients with SSD ( N = 48) were assigned to either MBGT in addition to German university-level treatment as usual (MBGT+TAU; n = 25) or TAU ( n = 23). At baseline and at four-week post-intervention, clinical parameters and OXT levels were determined. Results: Results indicate high feasibility and acceptance with a 95.7% adherence- and 94% retention- rate of MBGT in SSD. While no significant changes in empathy were observed, MBGT+TAU demonstrated a significant reduction in positive symptoms (Positive and Negative Syndrom Scale) compared to TAU at post-intervention. OXT levels were significantly increased in MBGT+TAU at post-intervention, suggesting a potential link between mindfulness and the oxytocinergic system in SSD. Additionally, improvements in various clinical parameters were indicated. Conclusion: The study contributes to the growing evidence supporting feasibility, acceptability, and positive effects of MBGT in outpatients with SSD, emphasizing the need for further research to solidify these findings. Overall, this work sheds first evidence on the intersection of mindfulness, oxytocin, and clinical outcomes in SSD. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2024 The Author(s).)
Databáze:	MEDLINE
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