Circulation of influenza viruses in the dog population in Kazakhstan (2023-2024).

Autor:	Glebova TI; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Klivleyeva NG; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Saktaganov NT; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Shamenova MG; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Lukmanova GV; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Baimukhametova AM; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Baiseiit SB; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Ongarbayeva NS; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan., Orynkhanov KA; Kazakh National Agrarian University, Almaty, Republic of Kazakhstan., Ametova AV; LLP «CVM Clinic», Almaty, Republic of Kazakhstan., Ilicheva AK; The Research and Production Center for Microbiology and Virology, Almaty, Republic of Kazakhstan.
Jazyk:	angličtina
Zdroj:	Open veterinary journal [Open Vet J] 2024 Aug; Vol. 14 (8), pp. 1896-1904. Date of Electronic Publication: 2024 Aug 31.
DOI:	10.5455/OVJ.2024.v14.i8.17
Abstrakt:	Background: Dogs in close contact with humans can serve as a source of potentially dangerous reassortant influenza viruses (IVs) with zoonotic potential. The dog's body can serve as a vessel for the emergence of new IVs. These new viruses can become a source of infection for other animals and humans. The potential for zoonotic transmission of IVs from dogs to humans poses a public health risk. Aim: Study of the circulation of IVs in the dog population in Almaty, Kazakhstan. Methods: Biosamples (oropharyngeal swabs and blood serum) from dogs were collected from veterinary clinics in Almaty in 2023-2024. Samples were screened using RT-PCR, HI assay, and ELISA. Results: RT-PCR analysis of 355 nasopharyngeal swabs showed the presence of influenza A virus (IAV) in 32 samples (9.01% of the total number of samples analyzed). When subtyping IAV H1N1 RNA was detected in 19 swabs (5.35%). IAV subtype could not be determined in 13 PCR-positive samples (3.66%). The genetic material of IAV H3N2, H5, H7, and H9, as well as coronavirus, bocavirus, and adenovirus has not been identified. In a serological analysis of 180 blood sera using ELISA, antibodies to IAV were detected in 5.56% ( n = 10). The results of the HI assay showed the presence of antihemagglutinins to A/H1N1pdm in 6.11% (11 samples), to A/H3N2 in 9.44% (17 samples), and no antibodies to IAV H5, H7, and type B were detected. Conclusion: There is no information about human infection with any canine influenza virus. However, many cases of infection in dogs with human IAVs H1N1, H1N1pdm09, and H3N2 have been described. When dogs are co-infected with different IAVs, new recombinant IAVs may emerge that can infect humans and other animals. Therefore, ongoing global surveillance of animal populations is necessary to monitor the evolution and circulation of viruses dangerous to public health. This is also important for timely preparation for the emergence of a new zoonotic influenza virus that has pandemic potential for humans. Competing Interests: The authors declare that there is no conflict of interest.
Databáze:	MEDLINE
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