Immune response and safety of co-administered peste des petits ruminants, contagious caprine pleuropneumonia, sheep and goat pox, and Pasteurellosis vaccines in goats.

Autor:	Hurisa TT; National Veterinary Institute, Bishoftu, Ethiopia., Tefera TA; National Veterinary Institute, Bishoftu, Ethiopia., Negatu R; National Veterinary Institute, Bishoftu, Ethiopia., Sori T; National Veterinary Institute, Bishoftu, Ethiopia., Deme BB; National Veterinary Institute, Bishoftu, Ethiopia., Yilma MA; Luna Export Abattoir, Central Oromia, Ethiopia., Tolossa W; Luna Export Abattoir, Central Oromia, Ethiopia., Legesse A; Luna Export Abattoir, Central Oromia, Ethiopia., Negewo A; Luna Export Abattoir, Central Oromia, Ethiopia., W/Medhin W; Luna Export Abattoir, Central Oromia, Ethiopia., Sherefa K; Luna Export Abattoir, Central Oromia, Ethiopia., Ayele G; Luna Export Abattoir, Central Oromia, Ethiopia., Geresu A; Department of Clinical Studies, Addis Ababa University College of Veterinary Medicine and Agriculture, Bishoftu, Ethiopia., Assefa E; Department of Clinical Studies, Addis Ababa University College of Veterinary Medicine and Agriculture, Bishoftu, Ethiopia., Dufera D; Department of Clinical Studies, Addis Ababa University College of Veterinary Medicine and Agriculture, Bishoftu, Ethiopia.
Jazyk:	angličtina
Zdroj:	Open veterinary journal [Open Vet J] 2024 Aug; Vol. 14 (8), pp. 1960-1967. Date of Electronic Publication: 2024 Aug 31.
DOI:	10.5455/OVJ.2024.v14.i8.25
Abstrakt:	Background: Infectious diseases such as peste des petits ruminants (PPRs), contagious caprine pleuropneumonia (CCPP), sheep and goat pox (SGPX), and pasteurellosis have considerable impacts on the optimal utilization of sheep and goat resources in Ethiopia. Immunization using multiple vaccines administered simultaneously has been suggested as a cost-effective and safe approach to controlling and preventing these diseases. Aim: The aim of this study was to assess the immunogenicity and safety of multiple vaccines administered simultaneously in goats. Methods: Sero-negative PPR, CCPP, SGPX, and Pasteurellosis goats were immunized with multiple vaccines. Goats vaccinated with a single vaccine against each disease served as a positive control. The immune response of the goats was assessed using serological tests, and any adverse effects were monitored. Results: The results of the present study showed that goats vaccinated with multiple vaccines exhibited a remarkable immune response against PPR, CCPP, and pasteurellosis. In contrast, they did not produce a protective immune response against sheep or goat pox. No adverse effects were observed with any of the vaccines. Conclusion: This study suggested that combined vaccines can be effective at inducing a protective immune response in goats. However, further research is needed to fully understand the immune response to combined vaccines. Competing Interests: The authors declare that they have no conflicts of interest.
Databáze:	MEDLINE
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