Increased extracellular free water is related to white matter hyperintensity burden.
| Autor: | Lei X; Department of Radiology, Lishui Hospital of Traditional Chinese Medicine affiliated with Zhejiang Chinese Medical University, Lishui, PR China., Qiu W; Department of Neurology, Lishui Hospital of Traditional Chinese Medicine affiliated with Zhejiang Chinese Medical University, Lishui, PR China., Xu Z; Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, PR China., Yu J; Department of Radiology, Lishui Hospital of Traditional Chinese Medicine affiliated with Zhejiang Chinese Medical University, Lishui, PR China., Lan H; Department of Radiology, Lishui Hospital of Traditional Chinese Medicine affiliated with Zhejiang Chinese Medical University, Lishui, PR China. |
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| Jazyk: | angličtina |
| Zdroj: | Acta radiologica (Stockholm, Sweden : 1987) [Acta Radiol] 2024 Oct; Vol. 65 (10), pp. 1265-1271. Date of Electronic Publication: 2024 Sep 23. |
| DOI: | 10.1177/02841851241282085 |
| Abstrakt: | Background: Extracellular free water (FW) has important roles in the occurrence and development of white matter hyperintensity (WMH). Purpose: To explore the correlations between FW and WMH burden. Material and Methods: A prospective analysis was conducted using magnetic resonance imaging (MRI) data from 126 individuals. WMH burden was determined based on WMH volumes and Fazekas scores from deep and periventricular white matter hyperintensity (DWMH and PWMH, respectively) in fluid-attenuated inversion recovery (FLAIR) images. FW values were taken from diffusion tensor imaging (DTI). Results: Univariate analysis showed that FW values were correlated with WMH burden, including WMH volumes and DWMH and PWMH Fazekas scores ( P < 0.05). After multivariate analysis, FW values were correlated with WMH volumes and DWMH and PWMH Fazekas scores when adjusted for age and hypertension ( P < 0.05). Conclusion: Using MRI, increasing extracellular FW was related to WMH burden. Competing Interests: Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. |
| Databáze: | MEDLINE |
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