Impact of spinach thylakoid extract-induced 12-week high-intensity functional training on specific adipokines in obese males.
| Autor: | Saeidi A; University of Kurdistan, Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, Sanandaj, Kurdistan, Iran., Motamedi P; Tarbiat Modares University, Faculty of Humanities, Department of Sport Science, Tehran, Iran., Hoteit M; California State University, Department of Kinesiology, Long Beach, CA, USA.; University of Tabriz, Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Tabriz, Iran., Sadek Z; Sultan Qaboos University, Department of Family Medicine and Public Health, Muscat, Oman.; Sultan Qaboos University Hospital, Department of Family Medicine and Public Health, Muscat, Oman., Ramadan W; The University of British Columbia, Department of Anesthesiology, Pharmacology and Therapeutics, Vancouver, Canada., Dara MM; Univ Rennes, M2S (Laboratoire Mouvement Sport, Santé) - EA, Rennes, France., Almaqhawi A; Institut International des Sciences du Sport (2I2S), Irodouer, France., Shahrbanian S; Kharazmi University, Department of Exercise Physiology, Faculty of Physical Education and Sports Science, Tehran, Iran., Abednatanzi H; Univ Rennes, M2S (Laboratoire Mouvement Sport, Santé) - EA, Rennes, France., Escobar KA; National Council for Scientific Research-Lebanon (CNRS-L), Food Science Unit, Beirut, Lebanon., Pashaei Z; Lebanese University, Faculty of Public Health, Section I, Beirut, Lebanon., Al Kiyumi MH; Lebanese University, Faculty of Public Health, Section I, Beirut, Lebanon.; Lebanese University, Laboratory of Motor System, Handicap and Rehabilitation (MOHAR), Faculty of Public Health, Beirut, Lebanon., Laher I; Lebanese International University (LIU), Lebanese Institutes for Biomedical Research and Application (LIBRA), Beirut, Lebanon., Zouhal H; Islamic Azad University, Department of Physical Education and Sport Science, Science and Research Branch, Tehran, Iran.; King Faisal University, Department of Family Medicine and Community, College of Medicine, Al Ahsa, Saudi Arabia. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of the International Society of Sports Nutrition [J Int Soc Sports Nutr] 2024 Dec; Vol. 21 (1), pp. 2398467. Date of Electronic Publication: 2024 Sep 22. |
| DOI: | 10.1080/15502783.2024.2398467 |
| Abstrakt: | Background: Obesity presents multifarious etiopathologies with its management being a global challenge. This article presents the first ever report on the impact of spinach thylakoid extract-induced high-intensity functional training (HIFT) on obesity management via regulating the levels of novel adipokine, C1q/TNF-related Protein-12 (CTRP-12), furin, and Krüppel-like factor 15 (KLF-15). Methods: Sixty-eight obese male subjects were randomly divided into four groups: control group (CG), supplement group (SG), training group (TG), and the combined training and supplement group (TSG). After initial assessments of all groups, the training group commenced a twelve-week HIFT using the CrossFit program (comprising of three training sessions per week, each lasting 30 min). Eligible candidates were randomly assigned to either receive thylakoid-rich spinach extract (5 g per day) or a matching placebo (5 g per day of corn starch, 30 min before lunch) for a total duration of 12 weeks. All required data and investigations were collected at 48 h pre- and post-training. Results: The results indicated a substantial correlation between exercise and the time of KLF-15, furin, and CTRP-12 demonstrating effect sizes of 0.3, 0.7, and 0.6, respectively. Additionally, the training and supplementation group (TSG) exhibited a substantial decrease in low-density lipoprotein (LDL), total cholesterol (TC), and triglyceride (TG) levels ( p < 0.0001). Concurrently, there was a significant increase in high-density lipoprotein-cholesterol (HDL-C) levels ( p = 0.0001). Furthermore, a notable difference between the groups emerged in HDL, LDL, TC, and TG levels, supported by effect sizes of 0.73, 0.86, 0.96, and 0.89, respectively ( p < 0.05). Conclusion: The study offered novel insights into the management of obesity using supplements induced by spinach-derived thylakoid extract during a 12-week HIFT program. The proposed combination intervention may reverse obesity-induced insulin resistance and metabolic dysfunctions by positive regulation of CTRP-12/adipolin and KLF15 and simultaneous suppression of furin levels. |
| Databáze: | MEDLINE |
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