Evaluating Scholastic Achievement in Pediatric Brain Tumor Survivors Compared With Healthy Controls.

Autor:	Mailhot Vega RB; Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida. Electronic address: rbmailhot@floridaproton.org., Indelicato DJ; Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida., Bradley JA; Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida., Markatia A; Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida., Mobley EM; Division of General Surgery and Surgical Oncology, Department of Surgery, University of Florida College of Medicine Jacksonville, Jacksonville, Florida., Sandler ES; Department of Pediatrics, Nemours Children's Specialty Clinic, Jacksonville, Florida., Aldana PR; Department of Neurosurgery, University of Florida College of Medicine Jacksonville, Jacksonville, Florida., Gomez JE; University of Pennsylvania Graduate School of Education, Philadelphia, Pennsylvania., Velasco D; Ensemble Learning, West Hollywood, California., Morris CG; Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida., Crisp AM; Center for Data Solutions, University of Florida College of Medicine Jacksonville, Jacksonville, Florida., Mendenhall NP; Department of Radiation Oncology, University of Florida College of Medicine, Jacksonville, Florida., Miller D; School of Human Development and Organizational Studies in Education, University of Florida College of Education, Gainesville, Florida.
Jazyk:	angličtina
Zdroj:	International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.
DOI:	10.1016/j.ijrobp.2024.09.033
Abstrakt:	Purpose: Radiation therapy (RT) causes cognitive deficits in pediatric brain tumor survivors (PBTS). Traditionally, this is measured using neuropsychological testing, which lack prediagnosis baseline and do not necessarily trigger action. This pilot project investigated a novel patient-centered outcome of scholastic performance using state-collected educational data. Methods and Materials: We retrospectively analyzed scholastic achievements in children residing in Florida. Eligibility in the treatment group received brain-directed RT between 2007 and 2020 at our institution. Controls were matched at a 3:1 ratio by age, grade, district, and free or reduced lunch eligibility. The Florida Department of Education provided educational records for both groups. Generalized linear mixed-effects models were used to predict scholastic outcomes with covariates age, time (binary value of pre- or post-RT), treatment group, and the primary independent variable as the interaction term between time and treatment. Scholastic data were matched with institutional clinical data. Results: A total of 50 PBTS and 150 matched controls were included for analysis. The median age of PBTS was 12, 12% identified as Black, and 18% identified as Hispanic. Fifty-two percent were eligible for free or reduced lunch. Forty percent received craniospinal irradiation, and 56% received chemotherapy. Post-RT PBTS had 21 times the odds of receiving accommodations (P = .006), twice the odds of being retained (P = .010), and 42% lower odds than controls receiving a passing mathematics score (P = .068). Conclusions: To our knowledge, this is the first American experience to successfully link individual scholastic and clinical data. Scholastic performance serves as a meaningful patient-centered outcome complementing the existing suite of neuropsychological testing. (Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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