Laryngeal chondrosarcoma, a 30-year series.

Autor: Lopes PF; Hospital Central do Funchal, Ilha da Madeira, Portugal. Electronic address: andreialopes10@gmail.com., Nascimento J; Centro Hospitalar Universitário de Lisboa Central, Lisboa, Portugal., Rocha G; Hospital Prof. Dr. Fernando Fonseca, Sintra, Portugal., Tinoco C; Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal., Hebe A; Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal., Montalvão P; Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal., Magalhães M; Instituto Português de Oncologia de Lisboa Francisco Gentil, Lisboa, Portugal.
Jazyk: angličtina
Zdroj: Acta otorrinolaringologica espanola [Acta Otorrinolaringol Esp (Engl Ed)] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1016/j.otoeng.2024.09.004
Abstrakt: Introduction and Objectives: Laryngeal chondrosarcoma is a rare laryngeal pathology arising from cartilaginous structures and is predominantly found in the cricoid cartilage. This study investigates its presentation, treatment modalities and patient outcomes.
Patients or Materials and Methods: Retrospective study of laryngeal chondrosarcoma cases followed from 1992 to 2022 in the Otorhinolaryngology department of a cancer center - Instituto Português de Oncologia de Lisboa. Statistical analysis was made with Microsoft Excel® and SPSS®.
Results: We identified 16 cases, of which two-thirds were male, with an average age of 59.6 years, and only 24% of them had a history of smoking. The commonest presentation was indolent dysphonia and/or dyspnea, and the posterior arch of the cricoid cartilage was the most affected place. Although histopathological studies after biopsy were often inconclusive, surgery emerged as the first-line of treatment for all patients. Larynx microsurgery with lesion debulking was the most frequent surgical approach (47%) followed by partial laryngectomy (24%). Neither adjuvant radiotherapy (RT) nor chemotherapy was administered in any of the cases. There was residual tumor in 23% of the cases so half of these patients were in watchful waiting while the other part underwent further microsurgery or total laryngectomy. Only one patient with recurrence received RT. Disease-specific survival rate at 1 and 5 years was 97% and 91%, respectively.
Conclusion: Laryngeal chondrosarcoma etiology is still unknown and is effectively treated with surgery, with a generally favorable prognosis. The main concern lies in its propensity to relapse, highlighting the importance of watchful follow-up.
(Copyright © 2024 Sociedad Española de Otorrinolaringología y Cirugía de Cabeza y Cuello. Published by Elsevier España, S.L.U. All rights reserved.)
Databáze: MEDLINE
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