Aquaporin4-IgG seropositivity significantly increases the risk of comorbid autoimmune diseases in NMOSD patients: population-based registry data.

Autor: Pekmezovic T; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia. pekmezovic@sezampro.rs., Jovicevic V; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Andabaka M; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Momcilovic N; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Veselinovic N; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Tamas O; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Budmkic M; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Todorovic S; Clinic of Neurology, Faculty of Medicine, Clinical Center Nis, University of Nis, Nis, Serbia., Jeremic M; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Dincic E; Clinic of Neurology, Military Medical Academy, Medical Faculty, Defense University, Belgrade, Serbia., Vojinovic S; Clinic of Neurology, Faculty of Medicine, Clinical Center Nis, University of Nis, Nis, Serbia., Andrejevic S; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.; Clinic of Allergology and Immunology, University Clinical Center of Serbia, Belgrade, Serbia., Mesaros S; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia., Drulovic J; Institute of Epidemiology, Faculty of Medicine, University of Belgrade, 11000, Belgrade, Serbia.; Clinic of Neurology, University Clinical Center of Serbia, Belgrade, Serbia.
Jazyk: angličtina
Zdroj: Journal of neurology [J Neurol] 2024 Dec; Vol. 271 (12), pp. 7525-7536. Date of Electronic Publication: 2024 Sep 22.
DOI: 10.1007/s00415-024-12698-2
Abstrakt: Background: The aim of our study was to estimate the frequency of autoimmune comorbidities, in NMOSD patients from the national Serbian NMOSD Registry.
Methods: Our study comprises 136 patients with NMOSD, diagnosed according to the NMOSD criteria 2015. At the time of the study, in the Registry were collected demographic and clinical data, including those related to the coexisting comorbidities and pathogenic autoantibodies. Not all patients were tested for all autoimmune antibodies. None of the seronegative aquaporin4-IgG (AQP4-IgG) NMOSD patients, included in the Registry, were positive for the myelin oligodendrocyte glycoprotein IgG.
Results: Among 136 NMOSD patients, 50 (36.8%) had at least one associated autoimmune disorder. AQP4-IgG was present in the sera from 106 patients (77.9%), the proportion of NMOSD patients with autoimmune comorbidities being significantly higher in the AQP4-IgG positive subgroup in comparison to the AQP4-IgG negative (p = 0.002). AQP4-IgG seropositive NMOSD patients had 5.2-fold higher risk of comorbid autoimmune diseases (OR = 5.2, 95% CI 1.4-18.5, p = 0.012). The most frequently reported diseases were autoimmune thyroid disease (15.4%), Sjogren's syndrome (11.0%), systemic lupus erythematosus (5.1%), myasthenia gravis (4.4%), and primary antiphospholipid antibody syndrome (2.9%). Antinuclear antibodies (ANAs) were frequently detected in the subgroup of NMOSD patients tested for this antibody (50/92; 54.3%). The higher frequency of ANAs and anti-extractable nuclear antigen autoantibodies, in the subgroups of AQP4-IgG-positive patients compared to the AQP4-IgG negative, tested for these antibodies, was statistically significant (p = 0.009, and p = 0.015, respectively).
Conclusion: In conclusion, based on our results, in a defined cohort with European ethnical background, a wide spectrum of autoimmune diseases is frequently associated with AQP4-IgG seropositive NMOSD patients.
Competing Interests: Declarations. Conflict of interest: Tatjana Pekmezovic has been an advisor or speaker for Sanofi-Genzyme, Medis, Hemofarm, Merck, Teva, and Roche. Vanja Jovicevic declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Marko Andabaka declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Nikola Momcilovic declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Nikola Veselinovic has been a speaker for Medis, Merck, Teva, Hemofarm, Novartis and Roche. Olivera Tamas has been a speaker for Medis, Merck, Teva, Hemofarm, Novartis and Roche. Maja Budimkic has been a speaker for Medis, Merck, Teva, Hemofarm, Novartis and Roche. Stefan Todorovic declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Marta Jeremic declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Evica Dincic has been an advisor or speaker for Medis, Merck, Teva, Hemofarm, Novartis, and Roche. Slobodan Vojinovic has been an advisor or speaker for Medis, Merck, Teva, Hemofarm, Novartis, and Roche. Sladjana Andrejevic has been speaker for Takeda Pharmaceuticals. Sarlota Mesaros has been an advisor or speaker for Medis, Merck, Teva, Hemofarm, Novartis, and Roche. Jelena Drulovic has been an advisor or speaker for Bayer HealthCare, Sanofi-Genzyme, Medis, Merck, Teva, Novartis, Biogen, Hemofarm, Pharma Swiss, Amicus, and Roche.
(© 2024. Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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