Prevalence and antibiotic susceptibility patterns of uropathogens in men with prostate cancer and benign prostate hyperplasia from Southwestern Nigeria.

Autor: Akinpelu SO; Department of Biological Sciences, College of Science and Technology, Covenant University, Ota, Nigeria. sharon.akinpelupgs@stu.cu.edu.ng., Olasehinde GI; Department of Biological Sciences, College of Science and Technology, Covenant University, Ota, Nigeria., Ikuerowo SO; Department of Surgery, Urology Division, Lagos State University College of Medicine, Ikeja, Nigeria., Akinnola OO; Department of Biological Sciences, College of Science and Technology, Covenant University, Ota, Nigeria.
Jazyk: angličtina
Zdroj: BMC microbiology [BMC Microbiol] 2024 Sep 21; Vol. 24 (1), pp. 361. Date of Electronic Publication: 2024 Sep 21.
DOI: 10.1186/s12866-024-03524-w
Abstrakt: Background: Epidemiological investigations have revealed an important association between infection, inflammation and prostate cancer. Certain bacterial species, such as Klebsiella spp, Escherichia coli, Pseudomonas spp, Proteus mirabilis, Chlamydia trachomatis have been linked to prostate cancer. This study aimed to examine the microbiota; specifically bacterial species that have been linked to prostate infections in the urine of individuals diagnosed with prostate cancer.
Results: Sixty-six prostate cancer patients and forty controls provided midstream urine samples. The urine samples were grown on suitable medium, and bacterial isolates were detected by standard microbiological methods. Additionally, the antibiotic sensitivity pattern of the bacterial isolates was analysed. A total of number of 72 bacterial isolates were obtained from the urine of study participants. The results showed the presence of Escherichia coli (50.0%), Pseudomonas aeruginosa (18.1%), Klebsiella spp (15.3%), Staphylococcus aureus (8.3%), Enterobacter spp (4.2%), and Proteus mirabilis (2.8%) in the urine. The most common bacterial species isolated from prostate cancer patients was Escherichia coli, which was susceptible to levofloxacin (100%), tobramycin (91.7%), and amikacin (62.5%).
Conclusions: This study's findings established the presence of bacteria previously linked to prostatitis. This report indicates a high prevalence of pro-inflammatory bacteria and uropathogens in the urinary tract of men diagnosed with prostate cancer.
(© 2024. The Author(s).)
Databáze: MEDLINE
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