Association between dust exposure and lung function levels in steelworkers: mediation analysis of inflammatory biomarkers.
| Autor: | Zheng Y; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Hu J; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Chen J; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Wang H; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Zhao Z; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Zhu H; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Li Z; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Wang N; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Chen X; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Liu M; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Luo Z; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Zhang S; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Zhang H; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Xuan X; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Li X; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Xue L; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China., Wang G; School of Emergency Management and Safety Engineering, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China. wangguoli@ncst.edu.cn., Wu J; Department of Epidemiology and Health Statistics, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China. wujianhui555@ncst.edu.cn.; Hebei Key Laboratory of Coal Health and Safety, School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan, 063210, China. wujianhui555@ncst.edu.cn. |
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| Jazyk: | angličtina |
| Zdroj: | International archives of occupational and environmental health [Int Arch Occup Environ Health] 2024 Nov; Vol. 97 (9), pp. 971-980. Date of Electronic Publication: 2024 Sep 21. |
| DOI: | 10.1007/s00420-024-02101-y |
| Abstrakt: | Purpose: This investigation aimed to examine the mediating effect of inflammatory biomarkers on the relationship between dust exposure and lung function levels among steelworkers. Methods: The study comprised 2,315 front-line workers employed at an iron and steel company in Tangshan, who underwent occupational health assessments through cluster sampling. Demographic and lifestyle data were collected via a self-administered questionnaire, while physical examinations measured parameters such as height and weight. Lung function was assessed using a portable pulmonary function tester (CHEST). Blood cell counts were uniformly analyzed using a Mindray fully automated biochemistry analyzer (BS-800). Inflammatory biomarkers, including leukocyte count, neutrophil count, lymphocyte count, and platelet count, were assessed, and the neutrophil-to-lymphocyte ratio and systemic immune inflammation index were computed. Generalized linear models and Spearman rank correlation analyses were employed to explore the interplay among dust exposure, inflammatory biomarkers, and alterations in lung function. A mediation analysis model was constructed to elucidate how inflammatory biomarkers mediate the relationship between dust exposure and lung function levels. Results: After adjusting for covariates, dust exposure was significantly associated with reduced lung function levels, with statistically significant differences observed between dust-exposed and non-exposed groups across various lung function indicators (P < 0.001). In the dust-exposed group, inflammatory biomarkers were elevated, showing significant correlations with FVC and FEV Conclusion: In conclusion, dust exposure poses a risk for decreased lung function levels. Inflammatory biomarkers derived from blood cells offer a valuable and easily obtainable means of identifying changes in lungfunction levels. Among these biomarkers, white blood cells, neutrophils, and the systemic immune inflammation index significantly mediate the association between dust exposure and lung function levels, although further exploration is needed to understand their underlying mechanisms. Competing Interests: Declarations Conflict of interest The authors declare no conflict of interest. Ethics approval All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This study was conducted in accordance with the Helsinki Declaration and approved by the Medical Ethics Review Committee of North China University of Science and Technology (No.16040). Consent to participate Informed consent was obtained from all individual participants included in the study. (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Databáze: | MEDLINE |
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