18 F-Fluorocholine-Positron Emission Tomography/Computerized Tomography (FCH PET/CT) Imaging for Detecting Abnormal Parathyroid Glands: Indication, Practice, Interpretation and Diagnostic Performance.

Autor: Noskovicova L; Department of Nuclear medicine, Comenius University Bratislava, St. Elisabeth Oncology Institute and Bory Hospital a.s., Bratislava, Slovakia., Balogova S; Department of Nuclear medicine, Comenius University Bratislava, St. Elisabeth Oncology Institute and Bory Hospital a.s., Bratislava, Slovakia; Service de médecine nucléaire, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France. Electronic address: Sona.balogova@fmed.uniba.sk., Aveline C; Service de médecine nucléaire, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France., Tassart M; Service de radiologie, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France., Zhang-Yin J; Department of Nuclear Medicine, Clinique Sud Luxembourg, Arlon, Belgium., Kerrou K; Service de médecine nucléaire, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France., Jaksic I; Department of Nuclear medicine, Comenius University Bratislava and Bory Hospital a.s., Bratislava, Slovakia., Montravers F; Service de médecine nucléaire, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France., Talbot JN; Service de médecine nucléaire, Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, France; Institut National des Sciences et Techniques Nucléaires (INSTN), Saclay, France.
Jazyk: angličtina
Zdroj: Seminars in nuclear medicine [Semin Nucl Med] 2024 Nov; Vol. 54 (6), pp. 875-895. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1053/j.semnuclmed.2024.08.002
Abstrakt: In patients with confirmed hyperparathyroidism (HPT) scheduled for surgical treatment, the preoperatory imaging permits to optimize the operatory protocol of parathyroidectomy (PTX), in particular by selecting those patients who can benefit from minimally invasive PTX (MIPTX). The MIPTX has the merit to shorten the operative time, incision length, and to reduce the operatory risks. With preoperative localization studies, the rate of PTX failure, in particular due to nonsuspected multiglandular or ectopic disease, has been profoundly decreased. The first cases of incidental localization of abnormal parathyroid glands (PTs) on FCH PET/CTs performed for another indication were reported more than one decade ago. Since then, significant amount of data from heterogeneous series of patients consistently confirmed better diagnostic performances of FCH PET/CT (sensitivity for detection of abnormal PT 97%, range 96%-98%) in comparison with other radiopharmaceuticals, ultrasonography or 4D-CeCT in localizing hyperfunctioning parathyroid glands (HFPTGs) in case of primary HPT. Utility of FCH PET/CT in case of renal HPT has been reported in fewer series. The article discusses and summarizes the bibliographic evidence on documented indications of FCH PET/CT in patients with HPT, its safety profile, the practice of FCH PET/CT and interpretation of FCH PET/CT findings, including potential interpretation pitfalls and tips to avoid them. Our real-world experience over 12 years reinforces published evidence supporting the use of FCH PET/CT as the first-line radionuclide imaging technique in patients with all types of HPT in whom surgery is an option.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: