Disruption of the Circulating Proteome in Neonates Receiving Extracorporeal Membrane Oxygenation Following Congenital Heart Disease Surgery: A Nested Case-Control Study.

Autor: Thomson LM; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO., Niemiec S; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO., Mancuso CA; Department of Biostatistics and Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO., Khailova L; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO., Ali E; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO., Syed A; Department of Pathology & Laboratory Medicine, Children's Hospital Colorado, Aurora, CO., Wolfe KR; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO., Zakrzewski J; Deparment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO., Stone M; Deparment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO., Hyslop R; Heart Institute, Children's Hospital Colorado, Aurora, CO., Frank BS; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO., Davidson JA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO. Electronic address: jesse.davidson@childrenscolorado.org.
Jazyk: angličtina
Zdroj: The Journal of pediatrics [J Pediatr] 2025 Jan; Vol. 276, pp. 114322. Date of Electronic Publication: 2024 Sep 19.
DOI: 10.1016/j.jpeds.2024.114322
Abstrakt: This nested case-control study identified broad dysregulation of the circulating proteome in neonates receiving postoperative extracorporeal membrane oxygenation support after congenital heart disease surgery, including differential responses in those not surviving to hospital discharge. Tissue hypoxia and mitochondrial-associated proteins may represent novel candidate biomarkers for poor extracorporeal membrane oxygenation outcomes.
Competing Interests: Declaration of Competing Interest This project was funded by National Institutes of HealthR01HL156936 (Davidson) and R38HL14351 StARR Award (Thomson). The funders had no role in study design, the collection, analysis and interpretation of data, the writing of the report, or the decision to submit the article for publication. The authors declare no conflicts of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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