Intracranial aneurysm stiffness assessment using 4D Flow MRI.

Autor: Koizumi S; Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan. Electronic address: sakoizumi-tky@umin.net., Kin T; Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan; Department of Medical Information Engineering, Graduate School of Medicine, The University of Tokyo, Japan., Sekine T; Department of Radiology, Nippon Medical School Musashi Kosugi Hospital, Japan., Kiyofuji S; Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan., Umekawa M; Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan., Saito N; Department of Neurosurgery, The University of Tokyo Hospital, Tokyo, Japan.
Jazyk: angličtina
Zdroj: Journal of neuroradiology = Journal de neuroradiologie [J Neuroradiol] 2024 Nov; Vol. 51 (6), pp. 101221. Date of Electronic Publication: 2024 Sep 19.
DOI: 10.1016/j.neurad.2024.101221
Abstrakt: Background: Although arterial stiffness is known as a biomarker for cardiovascular events and stroke, there is limited information in the literature regarding the stiffness of intracranial aneurysms. In this study, we aim to assess the stiffness of intracranial aneurysms using 4D Flow MRI.
Methods: A total of 27 aneurysms in 25 patients with internal carotid artery aneurysms were included in this study. Using 4D Flow MRI, we measured the arterial pulse wave form during a cardiac cycle at planes proximal and distal to the target aneurysm. The damping of these waveforms through the aneurysm was defined as the aneurysm damping index (ADI) and compared to the contralateral side. We also investigated the clinical factors related to the ADI.
Results: ADI assessment was successful in all cases. The average ADI was 1.18±0.28, which was significantly larger than 1.0 (P = 0.0027 [t-test]). The ADI on the aneurysm side was larger than on the contralateral side (1.19±0.30 vs 1.05±0.17, P = 0.029 [t-test]). On multivariate analysis, the use of beta-blockers (β=0.46, P = 0.015) and smoking history (β=-0.22, P = 0.024) showed a significant correlation with ADI.
Conclusion: We have proposed a novel method to observe arterial pulse wave dumping through intracranial aneurysm using 4D Flow MRI. The damping can be quantitatively observed, and the ADI has correlations with clinical factors such as antihypertensive drugs and smoking. Further studies should focus more on evaluating aneurysm stiffness and its clinical applications.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial or personal relationships that could be viewed as influencing the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.)
Databáze: MEDLINE
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