Rabies post-exposure prophylaxis: A retrospective analysis of timing of initiation and antibody responses in a Belgian cohort.

Autor: Hens M; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium. Electronic address: mhens@itg.be., Declercq S; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Berens-Riha N; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Maniewski U; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Theunissen C; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Van Den Broucke S; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., De Bièvre F; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Brosius I; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Liesenborghs L; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Van Dijck C; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Burm C; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Nauwelaers I; Department of viral diseases, Sciensano, Juliette Wytsmanstraat 14, 1050, Elsene, Belgium., Balliauw K; Hospital Pharmacy, University Hospital Antwerp, Drie Eikenstraat 655, 2650, Edegem, Belgium., Visser BJ; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Bottieau E; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium., Soentjens P; Department of Clinical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000, Antwerp, Belgium; Center for Infectious Diseases, Queen Astrid Military Hospital, Bruynstraat 1, 1120, Brussels, Belgium.
Jazyk: angličtina
Zdroj: Travel medicine and infectious disease [Travel Med Infect Dis] 2024 Nov-Dec; Vol. 62, pp. 102761. Date of Electronic Publication: 2024 Sep 19.
DOI: 10.1016/j.tmaid.2024.102761
Abstrakt: Background: We aimed to determine the timeliness of rabies post-exposure prophylaxis (PEP) and the proportion of individuals with an adequate antibody response post-PEP among those attending the Belgian national reference center.
Methods: Retrospective analysis of patient records who attended our center from 2018 to 2023. Delay was defined as rabies immunoglobulin (RIG) and vaccine initiation beyond 2 calendar days after exposure. Antibodies were measured by rapid fluorescent focus inhibition test (RFFIT) after PEP in high-risk exposures. A titer ≥0.5 IU/ml was considered adequate.
Results: We reviewed 317 patient records. Among individuals with inland exposure (n = 103), 85 % timely received PEP. Among travelers exposed abroad (n = 214), administration of RIG and vaccine initiation were timely in 30 % and 50 % of cases, respectively. An adequate antibody response was detected in 99.5 % (195/196) individuals.
Conclusion: Substantial PEP delays among travelers were observed. The robust antibody responses suggest that routine serological follow-up is not necessary for all patients.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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