Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation.

Autor: Landen JG; Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.; University of Wyoming Sensory Biology Center, Laramie, WY, USA., Vandendoren M; Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.; University of Wyoming Sensory Biology Center, Laramie, WY, USA., Killmer S; Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USA.; University of Wyoming Sensory Biology Center, Laramie, WY, USA., Bedford NL; Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USA., Nelson AC; Department of Zoology and Physiology, University of Wyoming, Laramie, WY, USA. anelso74@uwyo.edu.; University of Wyoming Sensory Biology Center, Laramie, WY, USA. anelso74@uwyo.edu.
Jazyk: angličtina
Zdroj: Communications biology [Commun Biol] 2024 Sep 20; Vol. 7 (1), pp. 1186. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1038/s42003-024-06781-7
Abstrakt: Social thermoregulation is a means of maintaining homeostatic body temperature. While adult mice are a model organism for studying both social behavior and energy regulation, the relationship between huddling and core body temperature (Tb) is poorly understood. Here, we develop a behavioral paradigm and computational tools to identify active-huddling and quiescent-huddling as distinct thermal substates. We find that huddling is an effective thermoregulatory strategy in female but not male groups. At 23 °C (room temperature), but not 30 °C (near thermoneutrality), huddling facilitates large reductions in Tb and Tb-variance. Notably, active-huddling is associated with bidirectional changes in Tb, depending on its proximity to bouts of quiescent-huddling. Further, group-housed animals lacking the synaptic scaffolding gene Shank3b have hyperthermic Tb and spend less time huddling. In contrast, individuals lacking the cold-sensing gene Trpm8 have hypothermic Tb - a deficit that is rescued by increased huddling time. These results reveal how huddling behavior facilitates acute adjustments of Tb in a state-dependent manner.
(© 2024. The Author(s).)
Databáze: MEDLINE
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