Cardiovascular outcomes in Parkinson's disease patients from a retrospective cohort study.

Autor: Lim S; Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Republic of Korea., Yum YJ; Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea., Kim JH; Korea University Research Institute for Medical Bigdata Science, Korea University College of Medicine, Seongbuk-Gu, Seoul, Republic of Korea., Lee CN; Department of Neurology, Korea University Anam Hospital, Seoul, Republic of Korea., Joo HJ; Division of Cardiology, Department of Internal Medicine, Korea University Anam Hospital, Seoul, Republic of Korea. drjoohj@gmail.com.; Korea University Research Institute for Medical Bigdata Science, Korea University College of Medicine, Seongbuk-Gu, Seoul, Republic of Korea. drjoohj@gmail.com.; Department of Medical Informatics, Korea University College of Medicine, Seoul, Korea. drjoohj@gmail.com., Kwon DY; Department of Neurology, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, Republic of Korea. kwondoya@korea.ac.kr.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Sep 20; Vol. 14 (1), pp. 21928. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1038/s41598-024-72549-y
Abstrakt: Parkinson's disease (PD) reports high rates of morbidity and mortality, but the risk of adverse cardiovascular outcomes in patients with PD has not been fully elucidated. This bi-center retrospective cohort study using the electronic health records (EHR) database of two tertiary hospitals screened a total of 327,292 subjects who visited the outpatient clinic, and 1194 patients with PD were propensity score-matched with a control population. The primary outcome was the occurrence of major adverse cardiovascular events (MACE). Key secondary outcomes included all-cause death, cardiovascular (CV) death, stroke, myocardial infarction (MI), heart failure hospitalization and 30-day CV death. After PS matching, MACE occurrence was not significantly different between PD and non-PD groups (18.2% vs. 17.5%, log-rank p = 0.98). Key secondary outcomes were also similar between the two groups. In patients with PD, MACE rate, and also CV risk score, were higher in patients with more severe PD (according to Hoehn and Yahr scale and unified Parkinson's disease rating scale), and after multivariable analysis, PD severity was not an independent predictor of MACE. Patients with PD are at an increased risk of adverse cardiovascular outcomes, but the contribution from other common CV risk factors cannot be ignored. The management of prevalent CV risk factors is therefore important in mitigating adverse outcomes among patients with PD.
(© 2024. The Author(s).)
Databáze: MEDLINE
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