Intravenous arachnoid granulation hypertrophy in patients with Parkinson disease.

Autor: Leguizamon M; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., McKnight CD; Vanderbilt Medical Center, Department of Radiology and Radiological Sciences, Nashville, TN, USA., Ponzo T; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Elenberger J; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Eisma JJ; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Song AK; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Trujillo P; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Considine CM; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Donahue MJ; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA.; Vanderbilt Medical Center, Department of Psychiatry and Behavioral Sciences, Nashville, TN, USA.; Vanderbilt University, Department of Electrical and Computer Engineering, Nashville, TN, USA., Claassen DO; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA., Hett K; Vanderbilt Medical Center, Department of Neurology, Nashville, TN, USA. kilian.hett.1@vumc.org.
Jazyk: angličtina
Zdroj: NPJ Parkinson's disease [NPJ Parkinsons Dis] 2024 Sep 20; Vol. 10 (1), pp. 177. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1038/s41531-024-00796-x
Abstrakt: Intravenous arachnoid granulations (AGs) are protrusions of the arachnoid membrane into the venous lumen and function as contributors to the cerebrospinal fluid (CSF) flow circuit. Patients with Parkinson disease (PD) often present with accumulation of alpha synuclein. Previous works have provided evidence for neurofluid circulation dysfunction in neurodegenerative diseases associated with changes in CSF egress, which may have implications regarding AG morphology. The present study aims to investigate group differences in AG volumetrics between healthy and PD participants, as well as relationships between AG characteristics and clinical assessments. Generalized linear models revealed significant increases in AG volumetrics and number in PD compared to healthy controls. Partial Spearman-rank correlation analyses demonstrated significant relationships between AG metrics and motor and cognitive assessments. Finally, AG volumetrics were positively correlated with objective actigraphy measures of sleep dysfunction, but not self-report sleep symptoms.
(© 2024. The Author(s).)
Databáze: MEDLINE
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