Cilastatin, a new therapeutic promise for acute kidney injury.

Autor:	González-Nicolás MÁ; Renal Physiopathology Laboratory, Department of Nephrology, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Physiology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain; RICORS2040, Madrid, Spain., Lázaro A; Renal Physiopathology Laboratory, Department of Nephrology, Instituto de Investigación Sanitaria Gregorio Marañón, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Department of Physiology, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain; RICORS2040, Madrid, Spain. Electronic address: alberlaz@ucm.es.
Jazyk:	angličtina
Zdroj:	Kidney international [Kidney Int] 2024 Oct; Vol. 106 (4), pp. 560-562.
DOI:	10.1016/j.kint.2024.07.024
Abstrakt:	Acute kidney injury is a devasting clinical syndrome resulting from multiple causes, characterized by an abrupt deterioration of kidney function for which there is no pharmacologic treatment. Cilastatin has demonstrated direct nephroprotective effects in acute kidney injury and now is shown to be effective to specifically target therapeutically loaded nanoparticles to the proximal tubule to treat acute kidney injury. (Copyright © 2024 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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