Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.

Autor: Lohmann R; University of Rhode Island, Graduate School of Oceanography, South Ferry Road, Narragansett, RI 02882, USA. Electronic address: rlohmann@uri.edu., Abass K; University of Sharjah, College of Health Sciences, Department of Environmental Health Sciences, The United Arab Emirates; University of Oulu, Faculty of Medicine, Research Unit of Biomedicine and Internal Medicine, Finland., Bonefeld-Jørgensen EC; Aarhus University, Center for Arctic Health and Molecular Epidemiology, Department of Public Health, DK-8000 Aarhus C, Denmark; University of Greenland, Greenland Center for Health Research, GL-3905 Nuuk, Greenland., Bossi R; Aarhus University, Department of Environmental Science, Frederiksborgvej 399, DK-4000 Roskilde, Denmark., Dietz R; Aarhus University, Department of Ecoscience, Frederiksborgvej 399, DK-4000 Roskilde, Denmark., Ferguson S; Fisheries and Oceans Canada, Arctic Region, Winnipeg, MB R3T 2N6, Canada., Fernie KJ; Environment and Climate Change Canada, Ecotoxicology and Wildlife Health Division, 867 Lakeshore Road, Burlington, ON L7S 1A1, Canada., Grandjean P; University of Rhode Island, College of Pharmacy, Kingston, RI 02881, USA; University of Southern Denmark, Department of Public Health, DK-5230 Odense, Denmark., Herzke D; The Norwegian Institute of Public Health, Division of Climate and Environmental Health, P.O.Box 222, Skøyen 0213, Oslo, Norway; Norwegian Institute for Air Research, Hjalmar Johansen gt 14 9006 Tromsø, Norway., Houde M; Environment and Climate Change Canada, Aquatic Contaminants Research Division, 105 McGill Street, Montreal, QC H2Y 2E7, Canada., Lemire M; Université Laval, Centre de recherche du CHU de Québec, Département de médecine sociale et préventive & Institut de biologie intégrative et des systèmes, 1030 Av. de la Médecine, Québec City, QC G1V 0A6, Canada., Letcher RJ; Environment and Climate Change Canada, Ecotoxicology and Wildlife Health Division, Carleton University, National Wildlife Research Centre, Ottawa, ON K1A 0H3, Canada., Muir D; Environment and Climate Change Canada, Aquatic Contaminants Research Division, 897 Lakeshore Rd., Burlington, ON L7S 1A1, Canada., De Silva AO; Environment and Climate Change Canada, Aquatic Contaminants Research Division, 897 Lakeshore Rd., Burlington, ON L7S 1A1, Canada., Ostertag SK; University of Waterloo, School of Public Health, 200 University Ave W, Waterloo, Ontario, Canada., Rand AA; Carleton University, Department of Chemistry, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada., Søndergaard J; Aarhus University, Department of Ecoscience, Frederiksborgvej 399, DK-4000 Roskilde, Denmark., Sonne C; Aarhus University, Department of Ecoscience, Frederiksborgvej 399, DK-4000 Roskilde, Denmark., Sunderland EM; Harvard University, Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02138, United States., Vorkamp K; Aarhus University, Department of Environmental Science, Frederiksborgvej 399, DK-4000 Roskilde, Denmark., Wilson S; Arctic Monitoring and Assessment Programme (AMAP) Secretariat, The Fram Centre, Box 6606 Stakkevollan, 9296 Tromsø, Norway., Weihe P; The National Hospital of the Faroe Islands, Department of Research, Sigmundargøta 5, FO-100 Torshavn, The Faroe Islands; University of the Faroe Islands, Center of Health Science, Torshavn, The Faroe Islands. Electronic address: pal@health.fo.
Jazyk: angličtina
Zdroj: The Science of the total environment [Sci Total Environ] 2024 Dec 01; Vol. 954, pp. 176274. Date of Electronic Publication: 2024 Sep 18.
DOI: 10.1016/j.scitotenv.2024.176274
Abstrakt: This cross-cutting review focuses on the presence and impacts of per- and polyfluoroalkyl substances (PFAS) in the Arctic. Several PFAS undergo long-range transport via atmospheric (volatile polyfluorinated compounds) and oceanic pathways (perfluorinated alkyl acids, PFAAs), causing widespread contamination of the Arctic. Beyond targeting a few well-known PFAS, applying sum parameters, suspect and non-targeted screening are promising approaches to elucidate predominant sources, transport, and pathways of PFAS in the Arctic environment, wildlife, and humans, and establish their time-trends. Across wildlife species, concentrations were dominated by perfluorooctane sulfonic acid (PFOS), followed by perfluorononanoic acid (PFNA); highest concentrations were present in mammalian livers and bird eggs. Time trends were similar for East Greenland ringed seals (Pusa hispida) and polar bears (Ursus maritimus). In polar bears, PFOS concentrations increased from the 1980s to 2006, with a secondary peak in 2014-2021, while PFNA increased regularly in the Canadian and Greenlandic ringed seals and polar bear livers. Human time trends vary regionally (though lacking for the Russian Arctic), and to the extent local Arctic human populations rely on traditional wildlife diets, such as marine mammals. Arctic human cohort studies implied that several PFAAs are immunotoxic, carcinogenic or contribute to carcinogenicity, and affect the reproductive, endocrine and cardiometabolic systems. Physiological, endocrine, and reproductive effects linked to PFAS exposure were largely similar among humans, polar bears, and Arctic seabirds. For most polar bear subpopulations across the Arctic, modeled serum concentrations exceeded PFOS levels in human populations, several of which already exceeded the established immunotoxic thresholds for the most severe risk category. Data is typically limited to the western Arctic region and populations. Monitoring of legacy and novel PFAS across the entire Arctic region, combined with proactive community engagement and international restrictions on PFAS production remain critical to mitigate PFAS exposure and its health impacts in the Arctic.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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