Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium.

Autor: Koturbash I; Department of Environmental Health Sciences, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; Center for Dietary Supplements Research, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA; USP Botanical Dietary Supplements Admission Evaluation and Labeling Expert Committee, United States Pharmacopeial Convention (USP), Rockville, MD, USA., Yeager RP; Office of Dietary Supplement Programs, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, USA., Mitchell CA; Health and Environmental Sciences Institute (HESI), Washington, DC, USA. Electronic address: cmitchell@hesiglobal.org., Ferguson S; Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA., Navarro VJ; Department of Medicine, Jefferson Einstein Medical Center, Philadelphia, PA, USA., Paine MF; Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, WA, USA., Roe AL; USP Botanical Dietary Supplements Admission Evaluation and Labeling Expert Committee, United States Pharmacopeial Convention (USP), Rockville, MD, USA; Procter & Gamble Company, 8700 Mason-Montgomery Rd, Box 2006, Cincinnati, OH, 45040, USA.
Jazyk: angličtina
Zdroj: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2024 Nov; Vol. 153, pp. 105708. Date of Electronic Publication: 2024 Sep 19.
DOI: 10.1016/j.yrtph.2024.105708
Abstrakt: Botanical supplements and herbal products are widely used by consumers for various purported health benefits, and their popularity is increasing. Some of these natural products can have adverse effects on liver function and/or interact with prescription and over-the-counter (OTC) medications. Ensuring the safety of these readily available products is a crucial public health concern; however, not all regulatory authorities require premarket safety review and/or testing. To address and discuss these and other emerging needs related to botanical safety, a symposium was held at the Society of Toxicology Annual Meeting in Salt Lake City (UT) on March 11, 2024. The symposium addressed the latest research on botanical-induced liver toxicity and botanical-drug interactions, including new approach methods to screen for toxicity, challenges in assessing the safety of botanicals, and relating human adverse events to specific products. The presentations and robust panel discussion between the speakers and audience highlighted the need for further research and collaboration to improve the safety of botanical supplements and herbal products, with the ultimate goal of protecting consumer health. Although utility of many of the modern tools presented in the symposium requires further study, the synergistic efforts of diverse experts hold promise for effective prediction and evaluation of botanical-induced hepatotoxicity and botanical-drug interaction potential.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The following author initials are employed by the private sector: AR.
(Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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