Association Between Proton Pump Inhibitor Use and Overactive Bladder Risk in Adults: A Cross-sectional Study.

Autor: Du YZ; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Liu JH; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Zheng FC; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Hu HJ; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Dong QX; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Guo B; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Zhong JL; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China., Guo J; Department of Urology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China; Key Laboratory of Urinary System Diseases of Jiangxi Province, Nanchang, China. Electronic address: ndyfy02371@ncu.edu.cn.
Jazyk: angličtina
Zdroj: Urology [Urology] 2024 Sep 18. Date of Electronic Publication: 2024 Sep 18.
DOI: 10.1016/j.urology.2024.09.015
Abstrakt: Objective: To investigate the association between the use of proton pump inhibitors (PPIs) and overactive bladder (OAB) in adults.
Methods: This study adopts a cross-sectional approach to scrutinize data derived from the National Health and Nutrition Examination Survey (NHANES), spanning from 2007 to 2018. It employs multivariable logistic regression along with restricted cubic splines (RCS) to investigate the relationship between the use of PPI and the incidence of OAB. Additionally, through interaction and stratification analyses, the study delves into how specific factors may influence this correlation.
Results: A total of 24,458 adults participated in this study. Individuals using PPIs exhibited higher rates of nocturia, urge incontinence, and OAB compared to non-users. After full adjustment, PPI users had a significantly increased risk of developing OAB (OR=1.36, 95%CI: 1.17-1.60). Moreover, with each year of continued PPI usage, the frequency of OAB symptoms escalated by 3% (P = .01). Further examinations within various subgroups maintained a uniform direction in these effect estimates.
Conclusion: The findings of this research highlight a noteworthy positive link between the use of PPIs and the emergence of OAB among adults. Moreover, it was observed that an extended period of using PPIs correlates with a heightened likelihood of encountering OAB.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflict of interest.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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