Potassium nitrate suppresses hyperactivities of Vc neurons of the model with dentin hypersensitivity.

Autor: Sugawara S; Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan. Electronic address: kawasaki.shiori@nihon-u.ac.jp., Iwata K; Department of Physiology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan., Takamizawa T; Department of Operative Dentistry, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Biomaterials Science, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan., Miyazaki M; Department of Operative Dentistry, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Biomaterials Science, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan., Kobayashi M; Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan.
Jazyk: angličtina
Zdroj: Journal of oral biosciences [J Oral Biosci] 2024 Dec; Vol. 66 (4), pp. 41-48. Date of Electronic Publication: 2024 Sep 19.
DOI: 10.1016/j.job.2024.09.005
Abstrakt: Objective: Potassium nitrate (KNO 3 ) suppresses nociception induced by dental hypersensitivity (HYS). We aimed to examine the effects of KNO 3 on the neural activity of the trigeminal spinal subnucleus caudalis (Vc) in HYS model rats.
Methods: KNO 3 or vehicle was applied to the exposed dentin of HYS rats for 3 days. c-Fos expression and neuronal activity in the Vc after acetone treatment for cold stimulation were examined to evaluate the effects of KNO 3 application on dentin.
Results: The number of c-Fos-immunoreactive cells in the Vc was lower in the group that received KNO 3 (KNO 3 group) than in the group that received vehicle (control group). Spike firing of Vc neurons in response to cold stimulation of the dentin was recorded before and after KNO 3 application to the cavity, and the increased neural activity was effectively suppressed by KNO 3 application. Scanning electron microscopy revealed that the dentin tubules were not occluded by deposits in any of the groups.
Conclusions: KNO 3 -induced suppression of Vc neuronal activity does not involve physical occlusion of the dentin tubules but likely involves suppression of Aδ or C-fiber activities in the tooth pulp, resulting in the suppression of Vc neuronal activities.
Competing Interests: Declaration of competing interest This study was funded by Earth Corporation. S. Sugawara and K. Iwata received an honorarium from Earth Corporation. The sponsor had no control over the interpretation, writing, or publication of this work.
(Copyright © 2024 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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