Association between pulse wave velocity and white matter hyperintensities among older adults: A meta-analysis of cross-sectional and longitudinal studies.

Autor: Álvarez-Bueno C; Universidad de Castilla - La Mancha, Health and Social Research Center, Cuenca, Spain; Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 7500912, Chile., Medrano M; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Institute of Health Carlos III, Madrid 28029, Spain; ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, Pamplona 31006, Spain., Lucerón-Lucas-Torres M; Universidad de Castilla - La Mancha, Health and Social Research Center, Cuenca, Spain. Electronic address: MariaIsabel.Luceron@uclm.es., Otero-Luis I; Universidad de Castilla - La Mancha, Health and Social Research Center, Cuenca, Spain., López-López S; Castilla-La Mancha Health Services, SESCAM, Cuenca Hospital. C, Hermandad de Donantes de Sangre, 1, Cuenca 16.002, Spain., Lever-Megina CG; Universidad de Castilla - La Mancha, Health and Social Research Center, Cuenca, Spain., Cavero-Redondo I; Universidad de Castilla - La Mancha, Health and Social Research Center, Cuenca, Spain.
Jazyk: angličtina
Zdroj: Ageing research reviews [Ageing Res Rev] 2024 Nov; Vol. 101, pp. 102501. Date of Electronic Publication: 2024 Sep 18.
DOI: 10.1016/j.arr.2024.102501
Abstrakt: Background: Higher levels of pulse wave velocity (PWV) have been related with the presence of small vessel disease that could damage the brain, in which white matter hyperintensities (WMH) could be presented as consequence. This meta-analysis aims to examine the cross-sectional and longitudinal associations between PWV and the presence of WMH among older adults.
Methods: We searched PubMed, Scopus, and WOS until June 2024. Pooled Odds Ratio (p-OR) were estimated for the cross-sectional and longitudinal associations between PWV and WMH. In addition, we explored whether this associations could be modified by type of PWV measurement and study and sample characteristics.
Results: The p-OR between PWV and WMH was 1.16 (95 % CI, 1.10-1.22) for the cross-sectional and 1.07 (95 %, 1.00-1.15) for the longitudinal association. Similar figures were found by type of PWV measurement and no one of the explored characteristics modified this associations.
Conclusions: This meta-analysis revealed that the presence in and the long-term development of WMHs among older adults are more likely among those with elevated PWV.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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