Microbial colonization programs are structured by breastfeeding and guide healthy respiratory development.

Autor:	Shenhav L; Institute for Systems Genetics, New York Grossman School of Medicine, New York University, New York, NY, USA; Department of Microbiology, New York Grossman School of Medicine, New York University, New York, NY, USA; Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, New York, NY, USA. Electronic address: liat.shenhav@nyulangone.org., Fehr K; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Reyna ME; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Petersen C; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Dai DLY; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Dai R; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Breton V; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Rossi L; Department of Medicine, McMaster University, Hamilton, ON, Canada., Smieja M; Department of Medicine, McMaster University, Hamilton, ON, Canada., Simons E; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada., Silverman MA; Division of Infectious Disease, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Levy M; Institute for Immunology and Immune Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Bode L; Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA; Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), University of California, San Diego, La Jolla, CA, USA; Human Milk Institute (HMI), University of California, San Diego, La Jolla, CA, USA., Field CJ; Department of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada., Marshall JS; Department of Department of Microbiology & Immunology, Dalhousie University, Halifax, NS, Canada., Moraes TJ; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Mandhane PJ; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Turvey SE; Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada., Subbarao P; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada; Department of Physiology, University of Toronto, Toronto, ON, Canada. Electronic address: padmaja.subbarao@sickkids.ca., Surette MG; Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: surette@mcmaster.ca., Azad MB; Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada; Manitoba Interdisciplinary Lactation Centre (MILC), Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. Electronic address: meghan.azad@umanitoba.ca.
Jazyk:	angličtina
Zdroj:	Cell [Cell] 2024 Sep 19; Vol. 187 (19), pp. 5431-5452.e20.
DOI:	10.1016/j.cell.2024.07.022
Abstrakt:	Breastfeeding and microbial colonization during infancy occur within a critical time window for development, and both are thought to influence the risk of respiratory illness. However, the mechanisms underlying the protective effects of breastfeeding and the regulation of microbial colonization are poorly understood. Here, we profiled the nasal and gut microbiomes, breastfeeding characteristics, and maternal milk composition of 2,227 children from the CHILD Cohort Study. We identified robust colonization patterns that, together with milk components, predict preschool asthma and mediate the protective effects of breastfeeding. We found that early cessation of breastfeeding (before 3 months) leads to the premature acquisition of microbial species and functions, including Ruminococcus gnavus and tryptophan biosynthesis, which were previously linked to immune modulation and asthma. Conversely, longer exclusive breastfeeding supports a paced microbial development, protecting against asthma. These findings underscore the importance of extended breastfeeding for respiratory health and highlight potential microbial targets for intervention. Competing Interests: Declaration of interests M.B.A. receives research funding from the Canadian and US governments, the Bill and Melinda Gates Foundation, and the Garfield Weston Foundation. She holds a Canada Research Chair in Early Nutrition and the Developmental Origins of Health and Disease and is a fellow of the CIFAR Humans and the Microbiome program. She has consulted for DSM Nutritional Products, serves on the scientific advisory board for TinyHealth, and has received speaking honoraria from Prolacta Biosciences. She has contributed without remuneration to online courses on breast milk and the infant microbiome produced by Microbiome Courses. L.B. receives research funding from the United States National Institutes of Health and the Bill and Melinda Gates Foundation. L.B. is the UC San Diego Chair of Collaborative Human Milk Research endowed by the Family Larsson-Rosenquist Foundation in Switzerland. V.B. is currently an employee of F. Hoffman-La Roche Ltd.; however, the published work was done prior to her employment and does not involve/promote any of Roche’s materials or point of view. (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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