Utility of saturation trends to predict successful weaning of nasal CPAP in very preterm neonates - A prospective study.

Autor:	Abiramalatha T; Neonatal Intensive Care Unit; Kovai Medical Center and Hospital (KMCH), Coimbatore, India.; KMCH Research Foundation, Coimbatore, India., Govindaraju G; Neonatal Intensive Care Unit; Kovai Medical Center and Hospital (KMCH), Coimbatore, India., Rajaiah B; Neonatal Intensive Care Unit; Kovai Medical Center and Hospital (KMCH), Coimbatore, India., Chandrasekar P; Neonatal Intensive Care Unit; Kovai Medical Center and Hospital (KMCH), Coimbatore, India., Srinivas U; Neonatal Intensive Care Unit; Kovai Medical Center and Hospital (KMCH), Coimbatore, India., Ramakrishnan S; Neonatal Intensive Care Unit; Kovai Medical Center and Hospital (KMCH), Coimbatore, India.
Jazyk:	angličtina
Zdroj:	Journal of neonatal-perinatal medicine [J Neonatal Perinatal Med] 2024; Vol. 17 (5), pp. 647-651.
DOI:	10.3233/NPM-230192
Abstrakt:	Background: There is no objective criteria to wean CPAP in preterm neonates. We aimed to assess the accuracy of 'saturation trends' to predict successful CPAP discontinuation. Methods: We included very preterm neonates who required CPAP. Index tests were 'saturation trends'. Outcome was successful CPAP discontinuation, defined as baby stable in room air for 72 h. Results: We had 120 neonates with mean±SD gestation 28.6±1.8 weeks. 96 (80%) neonates had successful discontinuation and 24 (20%) failed. Neonates with successful discontinuation had significantly greater 'saturation trends' during 24 h before discontinuing CPAP compared to those who failed [64.3 (48.1-83.7) vs. 47.3 (23.0-65.0), p = 0.001]. Saturations > 95% while on CPAP with 21% FiO2 for > 60% time had 63% sensitivity and 70% specificity to predict successful CPAP discontinuation. Conclusion: 'Saturation trends' is a readily available objective parameter that can be used to guide weaning CPAP in preterm neonates.
Databáze:	MEDLINE
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