Antimicrobial Biomaterials Based on Physical and Physicochemical Action.

Autor: Nowotnick AG; Chair of Materials Science (CMS), Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Löbdergraben 32, 07743, Jena, Germany.; Jena School for Microbial Communication (JSMC), 07743, Neugasse 23, Jena, Germany., Xi Z; Chair of Materials Science (CMS), Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Löbdergraben 32, 07743, Jena, Germany.; Jena School for Microbial Communication (JSMC), 07743, Neugasse 23, Jena, Germany., Jin Z; Bioactive Glasses Group, Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Lessingstraße 12, 07743, Jena, Germany., Khalatbarizamanpoor S; Jena School for Microbial Communication (JSMC), 07743, Neugasse 23, Jena, Germany.; Institute of Medical Microbiology, Jena University Hospital, 07747, Am Klinikum 1, Jena, Germany., Brauer DS; Bioactive Glasses Group, Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Lessingstraße 12, 07743, Jena, Germany., Löffler B; Jena School for Microbial Communication (JSMC), 07743, Neugasse 23, Jena, Germany.; Institute of Medical Microbiology, Jena University Hospital, 07747, Am Klinikum 1, Jena, Germany., Jandt KD; Chair of Materials Science (CMS), Otto Schott Institute of Materials Research (OSIM), Friedrich Schiller University Jena, Löbdergraben 32, 07743, Jena, Germany.; Jena School for Microbial Communication (JSMC), 07743, Neugasse 23, Jena, Germany.
Jazyk: angličtina
Zdroj: Advanced healthcare materials [Adv Healthc Mater] 2024 Dec; Vol. 13 (32), pp. e2402001. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1002/adhm.202402001
Abstrakt: Developing effective antimicrobial biomaterials is a relevant and fast-growing field in advanced healthcare materials. Several well-known (e.g., traditional antibiotics, silver, copper etc.) and newer (e.g., nanostructured, chemical, biomimetic etc.) approaches have been researched and developed in recent years and valuable knowledge has been gained. However, biomaterials associated infections (BAIs) remain a largely unsolved problem and breakthroughs in this area are sparse. Hence, novel high risk and potential high gain approaches are needed to address the important challenge of BAIs. Antibiotic free antimicrobial biomaterials that are largely based on physical action are promising, since they reduce the risk of antibiotic resistance and tolerance. Here, selected examples are reviewed such antimicrobial biomaterials, namely switchable, protein-based, carbon-based and bioactive glass, considering microbiological aspects of BAIs. The review shows that antimicrobial biomaterials mainly based on physical action are powerful tools to control microbial growth at biomaterials interfaces. These biomaterials have major clinical and application potential for future antimicrobial healthcare materials without promoting microbial tolerance. It also shows that the antimicrobial action of these materials is based on different complex processes and mechanisms, often on the nanoscale. The review concludes with an outlook and highlights current important research questions in antimicrobial biomaterials.
(© 2024 The Author(s). Advanced Healthcare Materials published by Wiley‐VCH GmbH.)
Databáze: MEDLINE
Externí odkaz: