Correlation and Clinical Significance of HBD-2 and CXCL-1/2 Levels at Skin Lesions with Psoriasis Vulgaris Severity.

Autor:	Lin L; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Luo Q; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Gao X; Department of Dermatology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, China., Li Q; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Li W; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Zhou X; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Liu W; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Zhong X; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Yang Y; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China., Zhang X; Department of Dermatology, Guangzhou Dermatology Hospital, Guangzhou, China.
Jazyk:	angličtina
Zdroj:	Immunological investigations [Immunol Invest] 2024 Nov; Vol. 53 (8), pp. 1234-1249. Date of Electronic Publication: 2024 Sep 20.
DOI:	10.1080/08820139.2024.2395852
Abstrakt:	Objective: This study was performed to explore the clinical significance of the expression of human beta-defensin 2 (HBD-2) and chemokine ligand 1/2 (CXCL-1/2) in psoriasis vulgaris. Methods: This study retrospectively included the study group (n = 160) and control group (n = 100) for analysis. The levels of inflammatory indicators, blood biochemical indicators, and immune indicators using ELISA. The psoriasis area and severity index (PASI) was used to evaluate disease severity. Levels of HBD-2, CXCL-1, CXCL-2 and CCL20 were determined by RT-PCR. The correlations of HBD-2, CXCL-1 and CXCL-2 levels with CCL20 and PASI scores were analyzed. The diagnostic value of HBD-2, CXCL-1 and CXCL-2 in psoriasis vulgaris was analyzed by ROC curve. Results: HBD-2, CXCL-1 and CXCL-2 were highly expressed in the lesions of psoriasis vulgaris patients, and were positively correlated with CCL20 and PASI score. HBD-2, CXCL-1 and CXCL-2 alone or in combination had high diagnostic value for psoriasis vulgaris and severe psoriasis, and the combined diagnostic value of the three was higher than that of a single indicator. Conclusion: HBD-2, CXCL-1, and CXCL-2 levels are closely related to the severity of psoriasis vulgaris and can effectively diagnose the occurrence and progression of psoriasis vulgaris.
Databáze:	MEDLINE
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