Incidental findings in research brain MRI: Definition, prevalence and ethical implications.

Autor: de Jong KJ; Emergency Department, Epworth Healthcare, Melbourne, Victoria, Australia., Poon E; Department of Imaging, Monash Health, Melbourne, Victoria, Australia.; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia., Foo M; Department of Radiology, Austin Health, Melbourne, Victoria, Australia., Maingard J; School of Medicine, Deakin University, Geelong, Victoria, Australia.; Interventional Radiology, Austin Hospital, Melbourne, Victoria, Australia.; Interventional Radiology, St Vincent's Hospital, Melbourne, Victoria, Australia.; Interventional Radiology, Epworth Hospital, Melbourne, Victoria, Australia.; Endovascular Clot Retrieval (ECR) Service, Austin Hospital, Melbourne, Victoria, Australia., Kok HK; Interventional Radiology Service, Northern Imaging Victoria, Melbourne, Victoria, Australia.; Medicine (Northern Health), Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia., Barras C; Department of Radiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.; South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.; The University of Adelaide, Adelaide, South Australia, Australia., Yazdabadi A; Department of Medical Education, Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia.; Monash University, Eastern Health, Melbourne, Victoria, Australia., Shaygi B; London North West University Healthcare NHS Trust, London, UK., Fitt GJ; Department of Radiology, Austin Health, Melbourne, Victoria, Australia.; Department of Medicine and Radiology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia., Egan G; Monash Biomedical Imaging, Monash University, Melbourne, Victoria, Australia., Brooks M; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Radiology, Austin Health, Melbourne, Victoria, Australia.; School of Medicine, Deakin University, Geelong, Victoria, Australia.; NeuroInterventional Radiology Unit, Monash Health, Melbourne, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia., Asadi H; Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia.; Department of Radiology, Austin Health, Melbourne, Victoria, Australia.; School of Medicine, Deakin University, Geelong, Victoria, Australia.; NeuroInterventional Radiology Unit, Monash Health, Melbourne, Victoria, Australia.; The Florey Institute of Neuroscience and Mental Health, Melbourne, Victoria, Australia.
Jazyk: angličtina
Zdroj: Journal of medical imaging and radiation oncology [J Med Imaging Radiat Oncol] 2024 Sep 20. Date of Electronic Publication: 2024 Sep 20.
DOI: 10.1111/1754-9485.13744
Abstrakt: Radiological incidental findings (IFs) are previously undetected abnormalities which are unrelated to the original indication for imaging and are unexpectedly discovered. In brain magnetic resonance imaging (MRI), the prevalence of IFs is increasing. By reviewing the literature on IFs in brain MRI performed for research purposes and discussing ethical considerations of IFs, this paper provides an overview of brain IF research results and factors contributing to inconsistencies and considers how the consent process can be improved from an ethical perspective. We found that despite extensive literature regarding IFs in research MRI of the brain, there are major inconsistencies in the reported prevalence, ranging from 1.3% to 99%. Many factors appear to contribute to this broad range: lack of standardised definition, participant demographics variance, heterogenous MRI scanner strength and sequences, reporter variation and results classification. We also found significant discrepancies in the review, consent and clinical communication processes pertaining to the ethical nature of these studies. These findings have implications for future studies, particularly those involving artificial intelligence. Further research, particularly in relation to MRI brain IFs would be useful to explore the generalisability of study results.
(© 2024 Royal Australian and New Zealand College of Radiologists.)
Databáze: MEDLINE
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