Urdamycin V from Streptomyces sp induces p53 independent apoptosis in cervical cancer cells inconsiderate of HPV status and inhibited growth of gram-positive human pathogens.

Autor:	Dan VM; Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Thiruvananthapuram, India., Sanawar R; Cancer Biology Division, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India., Mohan GMG; Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Thiruvananthapuram, India., Cheriyan SP; Microbiology Division, Jawaharlal Nehru Tropical Botanic Garden and Research Institute, Thiruvananthapuram, India., Kumar TRS; Cancer Biology Division, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India.
Jazyk:	angličtina
Zdroj:	Natural product research [Nat Prod Res] 2024 Sep 20, pp. 1-5. Date of Electronic Publication: 2024 Sep 20.
DOI:	10.1080/14786419.2024.2405862
Abstrakt:	In cervical cancer, loss of p53 or mutant non-functional p53 and hyperactivated mTOR/Akt pathway positively correlates to cancer progression. Urdamycin V isolated from Streptomyces OA293 is a recently isolated novel angucycline derivative that in the present study showcased induction of p53 independent apoptosis in both HPV (Human papillomavirus) positive and negative cervical cancer cell lines. Apoptosis induction was via phosphorylation modulation in the cell growth regulating proteins along mTORC2/Akt/p38/Erk pathway. The compound was also tested against human pathogens and selectively inhibited gram-positive strains, Streptococcus pyogenes and Staphylococcus aureus . The present study put forward urdamycins as a potential therapeutic that places promise for further research.
Databáze:	MEDLINE
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