| Autor: |
Kim J; Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea., Lee Y; Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea., Kim J; Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea., Park CW; Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea., Song H; Barunbio Inc., Seoul 03722, Republic of Korea., Hong J; Barunbio Inc., Seoul 03722, Republic of Korea.; School of Chemical & Biomolecular Engineering, Yonsei University, Seoul 03722, Republic of Korea., Lee S; School of Mechanical Engineering, Chung-Ang University, Seoul 06974, Republic of Korea., Jung WH; Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Republic of Korea., Hong JH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea., Kim KH; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea., Lee W; Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea. |
| Abstrakt: |
Alopecia, while not life-threatening, significantly impacts mental health, identity, and self-esteem of those afflicted. Current pharmacological and surgical treatments often have side effects and are limited in their ability to regenerate hair follicles (HF). Therefore, effective solutions for alopecia remain elusive. We developed an innovative hair tonic capable of stimulating HF regeneration by harnessing abandoned electric energy generated during human activities, such as the frictional electric field from walking and the electric fields from electronic devices. We devised a convenient, non-volatile, and conductive hair tonic to capture these naturally occurring electric fields. We identified 6-pentyl-α-pyrone (6PP) from Trichoderma gamsii as an antifungal agent effective against the dandruff-associated fungus Malassezia that can influence alopecia and adopted it into our conductive bio-harvesting tonic (CBT). Testing on hair follicle dermal papilla cells (HFDPC) and SKH1 mice showed that CBT significantly enhanced HF proliferation and increased growth factors in vitro and in vivo . In SKH1 mice, application of CBT under electric stimulation visibly increased hair shaft length and follicle counts. Additionally, tests on actual human hair follicles demonstrated delayed hair follicle regression when electric stimulation and 6PP were applied. In conclusion, our innovative CBT offers a promising and convenient approach for improving hair growth and combating alopecia. |
